Browsing Department of Medical Pharmacology and Physiology (MU) by Thesis Department "Medical Pharmacology and Physiology (MU)"
Now showing items 21-40 of 67
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Efficacy of TNF inhibitor treatment in a model of heart failure and resulting cachexia
(University of Missouri--Columbia, 2007)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The aim this dissertation was to explore the efficacy of tumor necrosis factor (TNF) inhibitors in attenuating increases in both anorexia and the ... -
Endothelial phenotype differs by both sex and vessel function
(University of Missouri--Columbia, 2017)Endothelial cells (the cells that line our blood vessels) were once thought to be an inert cellophane-like wrapper separating flowing blood from tissue. However, as our understanding of the human body has progressed, we ... -
Exercise, FGF21, and PGC-1 : roles in hepatic metabolism
(University of Missouri--Columbia, 2014)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The liver is instrumental in maintaining euglycemia during times of fasting and exercise, and in-turn exercise is a stimulus that challenges the liver ... -
Expression of adiponectin receptors by vascular smooth muscle cells
(University of Missouri--Columbia, 2009)Adiponectin (APN) is a 30-kDA insulin-sensitizing protein with strong effects on the vasculature. It binds three receptors: AdipoR1, AdipoR2, and T-cadherin. APN and AdipoRs are well-studied in the vascular endothelium, ... -
Expression of IGF2R, IGF2, TGFß, and uPAR in a rat model of obesity /
(University of Missouri--Columbia, 2017)We tested the hypothesis that induction of obesity in lean Long Evans Tokushima Otsuka (LETO) and obesity-prone Otsuka Long Evans Tokushima Fatty (OLETF) would cause the insulin growth factor 2 receptor (IGF2R) and factors ... -
Functional and pharmacological importance of the composite ATP binding site 1 in CFTR chloride channels
(University of Missouri--Columbia, 2010)The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride ion channel whose defects cause the deadly genetic disease cystic fibrosis (CF). Like other ATP binding cassette (ABC) proteins, CFTR encompasses ... -
Functional differences between pericytes and vascular smooth muscle cells during vascular morphogenesis
(University of Missouri--Columbia, 2011)During vascular morphogenic events, mural cells are recruited to developing endothelial tubes to aid in stabilization and maturation of the new vessels. There are two known types of mural cells, pericytes and vascular ... -
Histone H3 phosphorylation and phosphoacetylation in the liver of rats treated in vivo with acute ethanol
(University of Missouri--Columbia, 2011)Epigenetic histone modification is emerging as a critical player in the cellular actions of ethanol. In this context, we administered ethanol intraperitoneally to rats, to mimic binge drinking in humans. A dose response ... -
Hypochlorous acid stimulates heme oxygenase-1 gene expression in human endothelial cells
(University of Missouri--Columbia, 2008)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] In the present study, we tested the hypothesis that Hypochlorous acid (HOCl) regulates the expression of the cytoprotective protein heme oxygenase-1 ... -
Lipotoxicity in smooth muscle
(University of Missouri--Columbia, 2006)Atherosclerosis and bladder dysfunction can both result from the high lipid levels that occur with obesity and diabetes and can cause cell dysfunction and death, termed lipotoxicity, in various cell types. However, ... -
Maladaptation of cardiac and skeletal muscle in chronic disease : effects of exercise
(University of Missouri--Columbia, 2007)The human genome is adapted for daily physical activity (85). Thus, a sedentary lifestyle is capable of promoting detrimental consequences to human health. The linkage between lack of sufficient physical activity and the ... -
The mechanism for paraquat toxicity involves oxidative stress and inflammation : a model for Parkinson's disease
(University of Missouri--Columbia, 2007)Parkinson's disease (PD) is a neurodegenerative disorder known to affect the dopaminergic neurons in the substantia nigra. Epidemiological studies have shown an increased risk of developing PD with exposure to paraquat. ... -
Mechanisms of adenosine monophosphate-activated protein kinase-induced preconditioning in ischemia/reperfusion
(University of Missouri--Columbia, 2007)We have previously demonstrated that consuming ethanol (ethanol preconditioning or EPC) at low levels 24 hrs prior to ischemia/reperfusion (I/R) prevents postischemic leukocyte-endothelial cell adhesive interactions (LEI) ... -
Mechanisms of BKCa channel agonist NS-1619-elicited protection against oxidative stress from venules to arterioles
(University of Missouri--Columbia, 2011)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Tissue ischemia occurs in patients with myocardial infarction, stroke and other vascular occlusive diseases. While restitution of blood supply is ... -
Membrane type 1 matrix metalloproteinase proteolytic activity in initial adhesive and invasive events of ovarian cancer metastasis
(University of Missouri--Columbia, 2014)Epithelial ovarian cancer (EOC) is one of the most common gynecologic malignancies, generally developing in women over the age of forty. When EOC are diagnosed prior to metastatic dissemination, the overall 5-year survival ... -
Metabolic and autonomic nervous system effects of bariatric surgery
(University of Missouri--Columbia, 2009)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Despite avid attempts, non-surgical methods such as diet aids, behavioral modification and exercise are typically unsuccessful in achieving long term ... -
Metabolic and functional consequences of adenylate kinase deficiency in skeletal muscle
(University of Missouri--Columbia, 2005)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The primary function of skeletal muscle is to generate tension, and this ultimately occurs through ATP utilization. An increase in ADP and a depression ... -
Microenvironmental regulation of ovarian cancer dissemination via activation of the Wnt signaling pathway
(University of Missouri--Columbia, 2012)Disseminating single cells and multicellular aggregates (MCAs) and experience compressive forces exerted upon them by ascites fluid and are exposed to lysophosphatidic acid, aberrantly adhesive mesothelium and a collagen-rich ... -
Molecular control of endothelial lumen formation by Rho GTPases in three dimensional collagen matrices
(University of Missouri--Columbia, 2008)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Rho GTPases regulate a diverse spectrum of cellular functions involved in vascular morphogenesis. Here, we show that Cdc42 and Rac1 play a key role ... -
Molecular control of endothelial tube formation from single and aggregated cells by lumen signalling complexes that contain MT1-MMP and CDC42 in 3D collagen matrices
(University of Missouri--Columbia, 2010)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The first blood vessels to form in the embryo are generated by vasculogenesis. New insight into vasculogenesis in mammals is emerging from studies of ...