• The contribution of titin to striated muscle shortening 

    Schuster, Joseph M. (University of Missouri--Columbia, 2008)
    Striated muscle shortens under various loads (i.e., performs work), which allows movement of the skeleton and pumping of blood throughout the circulatory system. The amount of work that a muscle can do is determined by the ...
  • The effect of troponin I phosphorylation on the steepness of the Frank-Starling relationship 

    Cornell, Timothy D. (University of Missouri--Columbia, 2013)
    Heart failure begins with a reduction in the contractile strength of the cardiac myocytes (systolic dysfunction.) Cardiac myofibrils compensate via sympathetic activation to maintain adequate cardiac output. Beta-adrenergic ...
  • Effects of ischemic metabolites and chronic exercise on cardiac myocyte function 

    Hinken, Aaron C., 1977- (University of Missouri--Columbia, 2005)
    During times of low blood flow (ischemia), concentrations of wastes increase in tissues, which can lead to decreased striated muscle contractile function. Acute cardiac contractile dysfunction during ischemia is likely ...
  • Thick filament regulation of myocardial contraction 

    Korte, F. Steven, 1975- (University of Missouri--Columbia, 2006)
    The ability of the heart to function as a pump is governed by mechanisms intrinsic to individual cardiac myocytes. The experiments in this dissertation were designed to examine the effects of sarcomere length and thick ...