Department of Medical Pharmacology and Physiology (MU): Recent submissions
Now showing items 1-20 of 76
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Mechanisms for chlorinated lipids in sepsis
(University of Missouri--Columbia, 2020)Sepsis induces the formation of proinflammatory chlorinated lipids, stimulates adhesive interactions between the endothelium and leukocytes/platelets, causes mast cell activation, disrupts the microvascular barrier and ... -
Contribution of TRPV4 to enhanced calcium cycling and cardiac arrhythmia following ischemia-reperfusion in aged mouse hearts
(University of Missouri--Columbia, 2020)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Cardiomyocyte Ca2+ homeostasis is altered with aging and predisposes the Aged heart to Ca2+ intolerance and arrhythmia. Transient Receptor ... -
Molecular mechanisms of action for CFTR potentiators
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] As the culprit behind cystic fibrosis (CF) is the dysfunction of the chloride channel cystic fibrosis transmembrane conductance regulator (CFTR), ... -
TRPV4 contributes to stretch-induced hypercontractility and time-dependent dysfunction in the aged heart
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Aims: Cardiovascular disease remains the greatest cause of mortality in Americans over 65. The stretch-activated Transient Receptor Potential Vanilloid-4 ... -
Functional recovery of the microcirculation during skeletal muscle regeneration
(University of Missouri--Columbia, 2018)Skeletal muscle has a remarkable capacity to regenerate following injury, and although muscle regeneration has been studied extensively, little is known about the recovery of the skeletal muscle microcirculation during ... -
Sodium-Glucose Cotransporter 2 Inhibitors regulate vascular cell function
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Vascular disease is the major cause of morbidity and mortality in diabetic patients. Although numerous factors contribute to the development of ... -
Physiological and pharmacological characterization of the N1303K mutant CFTR
(University of Missouri--Columbia, 2018)Background: N1303K, one of the common, severe disease-causing mutations in the CFTR gene, causes both defective biogenesis and gating abnormalities of the CFTR protein. The goals of the present study are to quantitatively ... -
Integrin adhesion response to chemical and mechanical stimulation
(University of Missouri--Columbia, 2017)It is well recognized that arterial stiffness increases with aging and aging-related diseases, such as hypertension. The mechanisms for the increase in stiffness have been largely thought to be the result of changes in the ... -
Endothelial phenotype differs by both sex and vessel function
(University of Missouri--Columbia, 2017)Endothelial cells (the cells that line our blood vessels) were once thought to be an inert cellophane-like wrapper separating flowing blood from tissue. However, as our understanding of the human body has progressed, we ... -
Chlorinated lipid induce inflammatory responses in the microcirculation
(University of Missouri--Columbia, 2017)Previous studies from our research group have shown that chlorinated lipid, generated from the neutrophil-myeloperoxidase (MPO) system, are elevated in a rat sepsis model as well as in plasma of septic patients. Other work ... -
Dendritic cells contribute to perivascular adipose tissue dysfunction in type 2 diabetes
(University of Missouri--Columbia, 2017)T2DM is a chronic disease characterized by low-grade inflammation in adipose tissue. Recent investigations have shown that a variety of immune cells can accumulate in adipose tissue contributing to the development of chronic ... -
Myofibrillar regulatory mechanisms of stretch activation in mammalian striated muscle
(University of Missouri--Columbia, 2017)Stretch activation is described as a delayed increase in force after an imposed stretch. This process is essential in the flight muscles of many insects and is also observed, to some degree, in mammalian striated muscles. ... -
Role of T-type Ca²⁺ channels in lymphatic pacemaking /
(University of Missouri--Columbia, 2017)Lymphatic smooth muscle (LSM) contracts spontaneously, actively returning interstitial fluid through a network of lymphatic capillaries and collecting lymphatic vessels to the great veins. Dysfunctional lymphatic contractions ... -
Expression of IGF2R, IGF2, TGFß, and uPAR in a rat model of obesity /
(University of Missouri--Columbia, 2017)We tested the hypothesis that induction of obesity in lean Long Evans Tokushima Otsuka (LETO) and obesity-prone Otsuka Long Evans Tokushima Fatty (OLETF) would cause the insulin growth factor 2 receptor (IGF2R) and factors ... -
Sex differences in cardiac structure and function of Zucker diabetic fatty male and female rats
(University of Missouri--Columbia, 2016)Cardiovascular disease (CVD) is the leading cause of death for American adults, and diabetes mellitus (DM) is an independent risk factor for CVD. Diabetic women, both pre- and postmenopausal, have a greater risk for CVD ... -
The transient receptor potential vanilloid 4 ion channel and calcium homeostasis in cardiomyocytes of aged mice
(University of Missouri--Columbia, 2016)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Aging and cardiovascular disease are critically linked and have now become a growing concern for the healthcare community. Unfortunately, medicine ... -
Attenuation of rapid onset vasodilation with advanced age : roles of adrenergic and endothelial signaling
(University of Missouri--Columbia, 2016)Rapid onset vasodilation (ROV) occurs immediately in response to skeletal muscle contraction and initiates a prompt increase in blood flow and oxygen delivery that facilitate the transition to exercise. Muscle blood flow ... -
The role of the age-dependent loss of [alpha](E)-catenin in increased acute kidney injury /
(University of Missouri--Columbia, 2015)The aging kidney undergoes structural and functional alterations which make it more susceptible to acute kidney injury (AKI). Previous studies in our laboratory have shown that the aging kidney has a marked loss of ... -
Contribution of AT1R mechanoactivation to the arterial myogenic response and its regulation by RGS5 protein in skeletal muscle arterioles
(University of Missouri--Columbia, 2015)Although intracellular mechanisms underlying the arteriolar myogenic response have been well-defined, the mechanotransduction events transducing the mechanical stimulus remain unclear. Recently, ligand-independent activation ... -
New gating states of Cystic Fibrosis transmembrane conductance regulator discovered via studying pathogenic mutations, pharmacological reagents and ATP analogs.
(University of Missouri--Columbia, 2016)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Cystic Fibrosis (CF), caused by the loss of function in the gene for the protein cystic fibrosis transmembrane conductance (CFTR), is one of the most ...