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Are any oral iron formulations better tolerated than ferrous sulfate?
(Family Physicians Inquiries Network, 2002)
Ferrous salt preparations (ferrous sulfate, ferrous gluconate, and ferrous fumarate) are equally tolerable. (Grade of recommendation: A, based on randomized controlled trial.) Controlled-release iron preparations cause ...
Do antioxidants (vitamins C, E) improve outcomes in patients with coronary artery disease?
(Family Physicians Inquiries Network, 2002)
Antioxidant supplements of vitamins E and C do not reduce cardiovascular death in people with coronary artery disease. Vitamin E supplementation, in a variety of doses, does not decrease the incidence of cardiovascular or ...
Does postcoital voiding prevent urinary tract infections in young women?
(Family Physicians Inquiries Network, 2002)
Healthy women who urinate within 15 minutes of sexual intercourse may be slightly less likely to develop a urinary tract infection (UTI) than women who do not urinate afterward (grade of recommendation: D, extrapolation ...
Does a low-salt diet reduce morbidity and mortality in congestive heart failure?
(Family Physicians Inquiries Network, 2002)
No randomized controlled trials (RCTs) have addressed the independent role of sodium restriction in the morbidity or mortality of congestive heart failure. However, current guidelines recommend sodium restriction for ...
How beneficial are thiazolidinediones for diabetes mellitus?
(Family Physicians Inquiries Network, 2002)
The thiazolidinediones pioglitazone (Actos) and rosiglitazone (Avandia) are effective at lowering fasting plasma glucose (FPG) and glycosylated hemoglobin (Hb A1c) in patients with type 2 diabetes when used either as ...
How effective are exercise and physical therapy for chronic low back pain?
(Family Physicians Inquiries Network, 2002)
Exercise is more effective for chronic low back pain than treatment with medication plus return to usual activity and as effective as conventional physiotherapy. The evidence is less consistent in showing that any particular ...
What is the most effective treatment for external genital warts?
(Family Physicians Inquiries Network, 2002)
Podofilox (Condylox), imiquimod (Aldara), cryotherapy, and surgical options all seem reasonable alternatives that are superior to podophyllin. (Grade of recommendation: B, based on systematic review.) No studies of surgical ...
What is the target for low-density lipoprotein cholesterol in patients with heart disease?
(Family Physicians Inquiries Network, 2002)
Large published randomized controlled trials (RCTs) show that pravastatin and simvastatin are well-tolerated and reduce major coronary events such as death, myocardial infarction, and revascularization by about 25%. The ...
What is the most effective treatment for acute low back pain?
(Family Physicians Inquiries Network, 2002)
Nonsteroidal anti-inflammatory drugs (NSAIDs) are more effective than placebo for pain relief in patients with acute low back pain (grade of recommendation: A). There is no consistent evidence that NSAIDs are more effective ...
When should acute nonvenereal conjunctivitis be treated with topical antibiotics?
(Family Physicians Inquiries Network, 2002)
Children with suspected or culture-proven acute nonvenereal bacterial conjunctivitis should be treated with topical antibiotics, which hastens clinical and microbiological remission and may prevent potentially serious ...
What is the best way to evaluate acute diarrhea?
(Family Physicians Inquiries Network, 2002)
Limited evidence delineates the relative probabilities of causes of acute diarrhea, typically defined as a diarrheal disease lasting 14 days or fewer, in the developed world. Viruses (rotavirus, Norwalk, and other enteric ...
What is the best treatment for impacted cerumen?
(Family Physicians Inquiries Network, 2002)
Docusate sodium given 15 minutes before irrigation is most effective for facilitating cerumen removal during a single office visit. (Grade of recommendation: B, based on head-to-head trials that lacked irrigationonly arms.) ...
What is the prognosis for acute low back pain?
(Family Physicians Inquiries Network, 2002)
The proportion of patients who are pain free or completely recovered after an acute episode of low back pain within 2 weeks to 6 months ranges from 21% to 90%, depending on the population studied and the method of measuring ...
When should patients with asymptomatic aortic stenosis be evaluated for valve replacement?
(Family Physicians Inquiries Network, 2002)
For patients whose echocardiograms show advanced calcification of the aortic valves, a jet velocity of > 4.0 m/s, or a progression in jet velocity of 0.3m/s/year; and for patients who have an abnormal exercise response or ...
What are the treatment options for SSRI-related sexual dysfunction?
(Family Physicians Inquiries Network, 2002)
Substituting bupropion, nefazodone, or mirtazapine is beneficial. (Grade of recommendation: B, randomized controlled trials [RCTs].) Augmentation therapy with amantadine, bupropion, and buspirone is no better than placebo. ...
Is prostate-specific antigen (PSA) screening indicated for any subgroup of men?
(Family Physicians Inquiries Network, 2002)
Although African American men, men with a first-degree relative with prostate cancer (CaP), and older men constitute higher-risk subgroups, no well-designed randomized controlled trials are available that show PSA testing ...
Does ambulatory blood pressure monitoring aid in the management of patients with hypertension?
(Family Physicians Inquiries Network, 2002)
Twenty-four hour ambulatory blood pressure monitoring (ABPM) has a higher correlation with target end-organ damage than standard office measurements and is superior for risk stratification. Because it is more complicated ...
In patients with a previous CVA, do antioxidants protect against subsequent stroke?
(Family Physicians Inquiries Network, 2002)
Most recent randomized controlled clinical trials have not found a benefit in antioxidants (vitamin C, vitamin E, and/or beta-carotene) for preventing cardiovascular disease, including stroke. These recent clinical studies ...
How effective are pharmacologic agents for alcoholism?
(Family Physicians Inquiries Network, 2002)
Naltrexone (ReVia) and nalmefene (Revex) are the most effective agents for treating alcoholism. Acamprosate is effective but not available in the United States. Serotonergic agents, selective serotonin reuptake inhibitors ...
Is there a role for theophylline in treating patients with asthma?
(Family Physicians Inquiries Network, 2002)
With adults, oral theophylline may help lower the dosage of inhaled steroids needed to control chronic asthma. It offers no benefit for acute asthma exacerbations. For children, intravenous aminophylline may improve the ...