How beneficial are thiazolidinediones for diabetes mellitus?

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How beneficial are thiazolidinediones for diabetes mellitus?

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Title: How beneficial are thiazolidinediones for diabetes mellitus?
Author: Culhane, Nicole S.; Graves, Rebecca S.
Keywords: pioglitazone
rosiglitazone
fasting plasma glucose
type 2 diabetes
Date: 2002-05
Publisher: Family Physicians Inquiries Network
Citation: Journal of Family Practice, 51(5) 2002: 424.
Abstract: The thiazolidinediones pioglitazone (Actos) and rosiglitazone (Avandia) are effective at lowering fasting plasma glucose (FPG) and glycosylated hemoglobin (Hb A1c) in patients with type 2 diabetes when used either as monotherapy or in combination with sulfonylureas, metformin, or insulin. The glucose-lowering effects appear comparable with those of sulfonylureas and metformin alone. Currently, there are no randomized trials directly comparing patient-oriented outcomes of the thiazolidinediones with those of sulfonylureas and metformin. Grade of recommendation: B (on the basis of extrapolations from randomized trials and low quality randomized trials).
URI: http://hdl.handle.net/10355/2847

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