Do glucosamine or chondroitin cause regeneration of cartilage in osteoarthritis?

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Do glucosamine or chondroitin cause regeneration of cartilage in osteoarthritis?

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Title: Do glucosamine or chondroitin cause regeneration of cartilage in osteoarthritis?
Author: Priebe, David; McDiarmid, Todd; Mackler, Leslie
Keywords: chondrocyte growth
radiographic progression
joint space narrowing
Date: 2003-03
Publisher: Family Physicians Inquiries Network
Citation: Journal of Family Practice, 52(3) 2003: 237-239.
Abstract: No direct evidence suggests glucosamine or chrondroitin cause regeneration of cartilage in osteoarthritis. Use of glucosamine sulfate in knee osteoarthritis prevents joint space narrowing on radiographs (strength of recommendation [SOR]: B, based on 1 randomized controlled trial). Intramuscular chondroitin polysulfate prevents radiographic progression of finger osteoarthritis (SOR: B, based on 1 randomized controlled trial). Both chondroitin sulfate and glucosamine sulfate stimulate chondrocyte growth in vitro and in animal models (SOR: D, based on several bench research studies).
URI: http://hdl.handle.net/10355/2931

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