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dc.contributor.authorSchreck, Jennifereng
dc.contributor.authorKelsberg, Garyeng
dc.contributor.authorRich, Joanneeng
dc.date.issued2003-11eng
dc.description.abstractNo studies clearly demonstrate the best initial treatment for Parkinson's disease. Levodopa improves motor function in Parkinson's disease; however, long-term use is associated with irreversible dyskinesias and motor fluctuations. Compared with placebo, selegiline improves the motor symptoms of Parkinson's disease and allows a physician to delay the introduction of levodopa by 9 to 12 months (strength of recommendation [SOR]: A, based on randomized controlled trials). Dopamine agonists—alone or combined with levodopa—have fewer associated dyskinesias and other motor complications but produce lower scores on activities of daily living and Unified Parkinson's Disease Rating Scale (UPDRS) when compared with levodopa alone (SOR: A, based on systematic reviews of randomized controlled trials). Drug choices should be based on each patient's individual symptoms and response to medication.eng
dc.identifier.citationJournal of Family Practice, 52(11) 2003: 897-899.eng
dc.identifier.urihttp://hdl.handle.net/10355/2962eng
dc.languageEnglisheng
dc.publisherFamily Physicians Inquiries Networkeng
dc.relation.ispartofClinical Inquiries, 2003 (MU)eng
dc.relation.ispartofcollectionUniversity of Missouri-Columbia. School of Medicine. Department of Family and Community Medicine. Family Physicians Inquiries Networkeng
dc.rightsOpenAccess.eng
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.eng
dc.subjectdyskinesiaseng
dc.subjectmotor functioneng
dc.subject.lcshParkinson's disease -- Treatmenteng
dc.subject.lcshSelegilineeng
dc.subject.lcshAntiparkinsonian agentseng
dc.subject.lcshMovement disorderseng
dc.subject.lcshDopamine Agonistseng
dc.titleWhat is the best initial treatment of Parkinson's disease?eng
dc.typeArticleeng


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