What nonhormonal therapies are effective for postmenopausal vasomotor symptoms?

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What nonhormonal therapies are effective for postmenopausal vasomotor symptoms?

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/2981

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Title: What nonhormonal therapies are effective for postmenopausal vasomotor symptoms?
Author: Brewer, Dan; Nashelsky, Joan
Keywords: selective serotonin reuptake inhibitors
soy products
exercise
hormone replacement therapy (HRT)
Date: 2003-04
Publisher: Family Physicians Inquiries Network
Citation: Journal of Family Practice, 52(4) 2003: 324-329.
Abstract: Regular exercise may reduce vasomotor symptoms of menopause (strength of recommendation [SOR]: C—single observational study). Soy products/isoflavones, either through diet or supplementation, may reduce the incidence of hot flushes (SOR: D—inconsistent results of randomized trials). Clonidine, as an oral or transdermal preparation, reduces hot flushes (SOR: A—randomized clinical trials), as does gabapentin (SOR: A— single randomized clinical trial). In cancer patients who have had surgical menopause, selective serotonin reuptake inhibitors and megestrol (Megase) have been effective in reducing hot flushes (SOR: A; B for extrapolation to the general population). Other therapies—including Bellergal (a combination of belladonna, ergotamine, and phenobarbital), methyldopa, evening primrose oil, maiquan, flaxseed, ginseng, and topical wild yam extract—have not been effective. Black cohosh may be effective, but the evidence for this is of poor quality (SOR: C).
URI: http://hdl.handle.net/10355/2981

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