• Does acyclovir help herpes simplex virus cold sores if treatment is delayed? 

    Madigosky, Wendy S.; Meadows, Susan E. (Family Physicians Inquiries Network, 2004-11)
    When herpes simplex virus (HSV) type 1 lesions are in the papule or vesicle stage, there is no benefit to starting oral acyclovir (strength of recommendation [SOR]: C, based on expert opinion). However, topical acyclovir ...