Are inhalers with spacers better than nebulizers for children with asthma?

Abstract

Metered-dose inhalers with a spacer (MDI/S) are as good as, or better than, nebulizers for children with asthma. This is based on numerous randomized controlled trials that compared outcomes such as hospital admission rates, asthma severity scores, and pulmonary function scores (strength of recommendation: A, based on consistent randomized controlled trials and meta-analysis).