Do ACE inhibitors prevent nephropathy in type 2 diabetes without proteinuria?

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Do ACE inhibitors prevent nephropathy in type 2 diabetes without proteinuria?

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/3022

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Title: Do ACE inhibitors prevent nephropathy in type 2 diabetes without proteinuria?
Author: Sferra, Lisa; Kelsberg, Gary; Dodson, Sherry
Keywords: cardiovascular risk factor
albumin excretion rate
microalbuminuria
Date: 2004-01
Publisher: Family Physicians Inquiries Network
Citation: Journal of Family Practice, 53(1) 2004: 68-69.
Abstract: Angiotensin-converting enzyme (ACE) inhibitors make a significant difference for patients with diabetes as a whole. If patients both with and without microalbuminuria are included together, ACE inhibitors significantly reduce the progression of the albumin excretion rate (strength of recommendation [SOR]: A, based on multiple randomized controlled trials) and the development of overt nephropathy (SOR: A, based on 1 randomized controlled trial). However, studying diabetes without microalbuminuria separately, the effect of ACE inhibitors on progression to nephropathy does not reach statistical significance. This applies to both type 1 and 2 diabetes (SOR: A, based on randomized controlled trials with heterogenous results). Results are contradictory regarding whether ACE inhibition delays new onset of diabetic microalbuminuria.
URI: http://hdl.handle.net/10355/3022

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