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    Do ACE inhibitors prevent nephropathy in type 2 diabetes without proteinuria?

    Sferra, Lisa
    Kelsberg, Gary
    Dodson, Sherry
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    [PDF] DoACEInhibitorsPreventNephropathy.pdf (77.17Kb)
    Date
    2004
    Format
    Article
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    Abstract
    Angiotensin-converting enzyme (ACE) inhibitors make a significant difference for patients with diabetes as a whole. If patients both with and without microalbuminuria are included together, ACE inhibitors significantly reduce the progression of the albumin excretion rate (strength of recommendation [SOR]: A, based on multiple randomized controlled trials) and the development of overt nephropathy (SOR: A, based on 1 randomized controlled trial). However, studying diabetes without microalbuminuria separately, the effect of ACE inhibitors on progression to nephropathy does not reach statistical significance. This applies to both type 1 and 2 diabetes (SOR: A, based on randomized controlled trials with heterogenous results). Results are contradictory regarding whether ACE inhibition delays new onset of diabetic microalbuminuria.
    URI
    http://hdl.handle.net/10355/3022
    Part of
    Journal of family practice, 53, no. 01 (January 2004): 68-69.
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
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    • Clinical Inquiries, 2004

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