Do acetaminophen and an NSAID combined relieve osteoarthritis pain better than either alone?

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Do acetaminophen and an NSAID combined relieve osteoarthritis pain better than either alone?

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/3032

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Title: Do acetaminophen and an NSAID combined relieve osteoarthritis pain better than either alone?
Author: Buescher, Jennifer J.; Meadows, Susan E.
Keywords: pain relief
upper gastrointestinal (GI) bleeding
combination therapy
Date: 2004-06
Publisher: Family Physicians Inquiries Network
Citation: Journal of Family Practice, 53(6) 2004: 501-503.
Abstract: Combining nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen for short courses provides more relief of pain in osteoarthritis without an increase in side effects (strength of recommendation [SOR]=B). Combining acetaminophen at 4 g/d with an NSAID can also decrease the daily dose of NSAID required for pain relief, thus reducing the potential risk from higher-dose NSAID therapy (SOR=B). Over the long term, however, this combination may increase the risk of upper gastrointestinal (GI) bleeding more than that conferred by the NSAID alone (SOR=B). If combination therapy is necessary, limiting the dose of acetaminophen to ≤2 g/d minimizes gastrointestinal toxicity. Acetaminophen alone at the lowest dose to provide pain relief is the safest pharmacologic choice for patients with osteoarthritis.
URI: http://hdl.handle.net/10355/3032

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