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    Do acetaminophen and an NSAID combined relieve osteoarthritis pain better than either alone?

    Buescher, Jennifer J.
    Meadows, Susan E.
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    [PDF] DoAcetaminophenNSAIDCombined.pdf (86.04Kb)
    Date
    2004
    Format
    Article
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    Abstract
    Combining nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen for short courses provides more relief of pain in osteoarthritis without an increase in side effects (strength of recommendation [SOR]=B). Combining acetaminophen at 4 g/d with an NSAID can also decrease the daily dose of NSAID required for pain relief, thus reducing the potential risk from higher-dose NSAID therapy (SOR=B). Over the long term, however, this combination may increase the risk of upper gastrointestinal (GI) bleeding more than that conferred by the NSAID alone (SOR=B). If combination therapy is necessary, limiting the dose of acetaminophen to ≤2 g/d minimizes gastrointestinal toxicity. Acetaminophen alone at the lowest dose to provide pain relief is the safest pharmacologic choice for patients with osteoarthritis.
    URI
    http://hdl.handle.net/10355/3032
    Part of
    Journal of family practice, 53, no. 06 (June 2004): 501-503.
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
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    • Clinical Inquiries, 2004

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