Does acyclovir help herpes simplex virus cold sores if treatment is delayed?

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Does acyclovir help herpes simplex virus cold sores if treatment is delayed?

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Title: Does acyclovir help herpes simplex virus cold sores if treatment is delayed?
Author: Madigosky, Wendy S.; Meadows, Susan E.
Keywords: herpes labialis
prodrome stage
pain relief
lesion duration
Date: 2004-11
Publisher: Family Physicians Inquiries Network
Citation: Journal of Family Practice, 53(11) 2004: 923-924.
Abstract: When herpes simplex virus (HSV) type 1 lesions are in the papule or vesicle stage, there is no benefit to starting oral acyclovir (strength of recommendation [SOR]: C, based on expert opinion). However, topical acyclovir 5% cream applied 5 times a day decreases pain and the duration of hard crust (SOR: B, extrapolated from randomized controlled trials [RCTs]). If started at the onset of symptoms (during the prodrome stage), acyclovir (400 mg 5 times daily for 5 days) decreases pain and healing time to loss of crust and valacyclovir (2 g twice daily for 1 day) reduces the lesion duration and time to healing and may prevent lesion development (SOR: A, based on RCTs).
URI: http://hdl.handle.net/10355/3042

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