How effective is prophylactic therapy for gout in people with prior attacks?

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How effective is prophylactic therapy for gout in people with prior attacks?

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/3075

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Title: How effective is prophylactic therapy for gout in people with prior attacks?
Author: WinklerPrins, Vincent J.; Weismantel, Arlene McFarlin
Keywords: uricosurics
inflammatory response
Date: 2004-10
Publisher: Family Physicians Inquiries Network
Citation: Journal of Family Practice, 53(10) 2004: 837-838.
Abstract: Colchicine (strength of recommendation [SOR]: B, based on 1 double-blind crossover study), allopurinol (SOR: B, based on 2 cohort studies), and weight loss (SOR: B, based on 1 small cohort study) have been shown to reduce symptomatic recurrences of gout, although the data to support their use is limited. Some evidence suggests that despite their serum uric acid-lowering effects, uricosurics (such as probenecid) fail to reduce gout attacks (SOR: B, based on 2 cohort studies). We were unable to find any double-blind, placebo-controlled long-term outcome studies addressing this problem.
URI: http://hdl.handle.net/10355/3075

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