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    • Clinical Inquiries, 2004
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    What effect do inhaled steroids have on delaying the progression of COPD?

    Hansen, Laura
    Havemann, James
    Burroughs, Martha
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    [PDF] WhatEffectInhaledSteroids.pdf (82.78Kb)
    Date
    2004
    Format
    Article
    Metadata
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    Abstract
    The annual rate of decline in forced expiratory volume for 1 second (FEV1) has been researchers' gold standard as an objective measure for progression of chronic obstructive pulmonary disease (COPD). Inhaled corticosteroids (ICS) do not consistently have a statistically significant impact on FEV1 decline, and thus on the progression of COPD (strength of recommendation [SOR]: B, 2 conflicting meta-analyses and numerous conflicting randomized controlled trials). In those studies that did show improvements in FEV1 decline, the change does not appear to be clinically significant (7.7 to 9.0 mL/year). These findings do not take into account the potential impact of ICS on such patient oriented outcomes as exacerbation rates, quality of life, outpatient visits, hospitalization, and mortality.
    URI
    http://hdl.handle.net/10355/3211
    Part of
    Journal of family practice, 53, no. 10 (October 2004): 835-836.
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
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