What effect do inhaled steroids have on delaying the progression of COPD?

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What effect do inhaled steroids have on delaying the progression of COPD?

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/3211

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Title: What effect do inhaled steroids have on delaying the progression of COPD?
Author: Hansen, Laura; Havemann, James; Burroughs, Martha
Keywords: exacerbation frequency
diseasemoderating therapy
forced expiratory volume
Date: 2004-10
Publisher: Family Physicians Inquiries Network
Citation: Journal of Family Practice, 53(10) 2004: 835-836.
Abstract: The annual rate of decline in forced expiratory volume for 1 second (FEV1) has been researchers' gold standard as an objective measure for progression of chronic obstructive pulmonary disease (COPD). Inhaled corticosteroids (ICS) do not consistently have a statistically significant impact on FEV1 decline, and thus on the progression of COPD (strength of recommendation [SOR]: B, 2 conflicting meta-analyses and numerous conflicting randomized controlled trials). In those studies that did show improvements in FEV1 decline, the change does not appear to be clinically significant (7.7 to 9.0 mL/year). These findings do not take into account the potential impact of ICS on such patient oriented outcomes as exacerbation rates, quality of life, outpatient visits, hospitalization, and mortality.
URI: http://hdl.handle.net/10355/3211

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