Proteomics of canine lymphoma identifies potential cancer-specific protein markers

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Proteomics of canine lymphoma identifies potential cancer-specific protein markers

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[-] show simple item record McCaw, Dudley L. Chan, Arvan S. Stegner, Andrew L. Mooney, Brian P. Bryan, Jeffrey N. Turnquist, Susan E. Henry, Carolyn J. Alexander, Hannah, 1947- Alexander, Stephen, 1948- 2009-10-28T13:57:18Z 2009-10-28T13:57:18Z 2007-04 eng
dc.identifier.citation Clinical Cancer Research April 15, 2007 13, 2496 en
dc.identifier.issn 1557-3265
dc.description.abstract Purpose: Early diagnosis of cancer is crucial for the success of treatment of the disease, and there is a need for markers whose differential expression between disease and normal tissue could be used as a diagnostic tool. Spontaneously occurring malignancies in pets provide a logical tool for translational research for human oncology. Lymphoma, one of the most common neoplasms in dogs, is similar to human non-Hodgkin's lymphoma and could serve as an experimental model system. Experimental Design: Thirteen lymph nodes from normal dogs and 11 lymph nodes from dogs with B-cell lymphoma were subjected to proteomic analysis using two-dimensional PAGE separation and matrix-assisted laser desorption/ionization time-of-flight analysis. Results: A total of 93 differentially expressed spots was subjected to matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometry analysis, and several proteins that showed differential expression were identified. Of these, prolidase (proline dipeptidase), triosephosphate isomerase, and glutathione S-transferase were down-regulated in lymphoma samples, whereas macrophage capping protein was up-regulated in the lymphoma samples. Conclusions: These proteins represent potential markers for the diagnosis of lymphoma and should be further investigated in human samples for validation of their utility as diagnostic markers. en
dc.language.iso en_US en
dc.publisher American Association for Cancer Research en
dc.relation.ispartof Proteomics Center publications (MU) en
dc.subject cancer biomarkers en
dc.subject mass spectrometry en
dc.subject macrophage capping protein en
dc.subject triosephosphate isomerase en
dc.subject glutathione S-transferase en
dc.subject.lcsh Tumor markers en
dc.subject.lcsh Mass spectrometry en
dc.subject.lcsh Triose-phosphate isomerase en
dc.subject.lcsh Glutathione transferase en
dc.title Proteomics of canine lymphoma identifies potential cancer-specific protein markers en
dc.type Article en
dc.subject.discipline Life sciences
dc.relation.ispartofcommunity University of Missouri-Columbia. Christopher S. Bond Life Sciences Center. Proteomics Center

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