Does quinine reduce leg cramps for young athletes?

Abstract

Very little evidence exists regarding the use of quinine for cramps in young adult athletes. Quinine may be an effective treatment for heat cramps in athletes (strength of recommendation [SOR]: C, 1 case series involving 2 patients). Quinine is better established as an effective treatment for nocturnal leg cramps in the general adult population (SOR: A, 1 meta-analysis and 2 randomized controlled trials).