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    Do statins delay onset or slow progression of Alzheimer's dementia?

    Suchecki, Slade A.
    Aitken, Paul V., Jr.
    Potts, Rick
    Collins, Linda J.
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    [PDF] DoStatinsDelayOnset.pdf (48.86Kb)
    Date
    2005
    Format
    Article
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    Abstract
    Statins (coenzyme-A reductase inhibitors) should not be used with the single intent to delay the onset or slow the progression of dementia. Large randomized control trials (RCTs) found that the administration of a statin had no significant effect on preventing or slowing all-cause cognitive decline (strength of recommendation [SOR]: A, based on large RCTs with narrow confidence interval). Specifically, there is insufficient evidence that statins delay the onset or slow the progression of Alzheimer's dementia (SOR: B, based on systematic review with heterogeneity). While 3 epidemiologic studies have found a decreased incidence of dementia among those taking statins, these studies have significant methodological shortcomings and do not show a causal relationship (SOR: C, based on poor-quality studies).
    URI
    http://hdl.handle.net/10355/3287
    Part of
    Journal of family practice, 54, no. 07 (July 2005)
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
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