dc.contributor.author | Yousefi, Pouran | eng |
dc.contributor.author | Coffey, John B. | eng |
dc.date.issued | 2005 | eng |
dc.description.abstract | There is no single most effective modality for the treatment of fibromyalgia syndrome, and no objective comparison of the results from the different studies is available. Low-dose tricyclic antidepressants (TCAs) improve sleep quality and global well-being and have a moderate beneficial effect on tenderness and stiffness (strength of recommendation [SOR]: A, based on a systematic review of randomized controlled trials [RCTs]). Selective serotonin reuptake inhibitors (SSRIs) may moderately improve fibromyalgia-related symptoms (SOR: B, based on a few RCTs). The serotonin and norepinephrine reuptake inhibitors (SNRIs) duloxetine (Cymbalta) and milnacipran (Ixel, not currently available in the US) improve pain and other symptoms (SOR: B, based on single RCTs). Tramadol (Ultram) improves pain and other outcomes (SOR: A, based on a few RCTs). Cyclobenzaprine (Flexeril) improves both pain and sleep quality (SOR: A, based on a systematic review of RCTs). Aerobic exercise improves overall functional capacity and sense of well-being for patients with fibromyalgia (SOR: A, based on a systematic review of RCT). Cognitive behavioral therapy improves patients' self-reported symptoms (SOR: A, based on RCTs). | eng |
dc.identifier.uri | http://hdl.handle.net/10355/3290 | eng |
dc.language | English | eng |
dc.publisher | Family Physicians Inquiries Network | eng |
dc.relation.ispartofcollection | Clinical Inquiries, 2005 (MU) | eng |
dc.relation.ispartofcommunity | University of Missouri--Columbia. School of Medicine. Department of Family and Community Medicine. Family Physicians Inquiries Network | eng |
dc.relation.ispartofseries | Journal of family practice, 54, no. 12 (December 2005) | eng |
dc.rights | OpenAccess. | eng |
dc.rights.license | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License. | eng |
dc.subject | aerobic exercise | eng |
dc.subject | tricyclic antidepressants (TCAs) | eng |
dc.subject | symptom relief | eng |
dc.subject | selective serotonin reuptake inhibitors (SSRIs) | eng |
dc.subject.lcsh | Antidepressants | eng |
dc.subject.lcsh | Serotonin uptake inhibitors | eng |
dc.subject.lcsh | Fibromyalgia | eng |
dc.subject.lcsh | Exercise therapy | eng |
dc.subject.lcsh | Cognitive therapy | eng |
dc.title | For fibromyalgia, which treatments are the most effective? | eng |
dc.type | Article | eng |