2013 Dissertations (UMKC)
The items in this collection are the dissertations written by graduate students. Some items may be viewed only by members of the University of Missouri System and/or University of Missouri-Kansas City. Click on one of the browse buttons above for a complete listing of the works.
Items in MOspace are protected by copyright, with all rights reserved, unless otherwise indicated.
Collections in this community
Recent Submissions
-
The Role of Host Translation Initiation Factors eIF4H and eIF4A and the Exon Junction Complex in the Control of mRNA turnover and Translation by the Virion Host Shut off Protein of Herpes Simplex Virus
(2013)During lytic infections, the HSV Vhs endonuclease (UL41) degrades many viral and cellular mRNAs. This endonuclease activity is dependent upon the ability of Vhs to bind the host translation initiation factors eIF4AI/II and ... -
Beneath Mark Twain: Judgments of Justice and Gender in Twain's Early Western Writing, 1861-1873
(2013)By the time Samuel Clemens began writing journalism and crafting what he called the “sensation hoax” for Virginia City’s Territorial Enterprise in 1862, Americans had been devouring sensational novels and journalism by ... -
Development of Pentablock Copolymer Based Formulations for the Sustained Delivery of Protein Therapeutics in the Treatment of Posterior Segment Ocular Diseases
(2013)We have successfully synthesized pentablock (PB) copolymers comprised of various FDA approved polymer blocks such as polyethylene glycol (PEG), polycaprolactone (PCL), polylactic acid (PLA) and polyglycolic acid (PGA). PB ... -
The Cellular and Molecular Mechanisms of Prostaglandin E₂ in Myogenesis
(2013)Prostaglandin E₂ (PGE₂), the most abundant prostaglandin (PG) in our body, has multiple biological functions related to physiological activities and the development of diseases. Emerging evidence has shown that PGE2 plays ... -
The function of Drosophila Integrin-Dim7-Elmo-Mbc→Rac signaling pathway in the muscle attachment formation and maintenance
(2013)The Engulfment and Cell Motility (Elmo)-(Myoblast city) Mbc→Rac signaling pathway is evolutionarily conserved from C. elegans to vertebrates and is essential for many developmental processes, including phagocytosis and ... -
Novel Transporter Targeted Lipid Ester Prodrugs of Cidofovir and Sustained Release Formulations for Cytomegalovirus Infection
(2013)Cidofovir (CDF) has shown potential in vitro and in vivo antiviral activity against cytomegalovirus (CMV) retinitis. However, low CDF permeability due to its hydrophilic nature limits its effectiveness. Furthermore, ... -
Development Theory and the Cold War: A Historical Analysis of Latin American Structuralism from 1930 to 1970
(2013)Latin America has experimented with two different development strategies over the last two centuries. First, and currently, an “outward-oriented” program based on exports of primary commodities. Alternatively, for a few ... -
Provider Perceptions of a Mature School-Based Health Center's Effect on Adolescent Health and Wellness: A Case Study
(2015-06-02)School-based health centers (SBHCs) have emerged as a model of care that enhances utilization of health care services for U.S. adolescents. Staffed by interdisciplinary teams, physicians play a largely supervisory role ... -
Transporter-Targeted Prodrug Delivery to Improve Oral Bioavailability of Saquinavir
(2015-05-22)Saquinavir (SQV) is the first antiretroviral protease inhibitor approved by Food and Drug Administration in the United States for the treatment of HIV infection due to its potent anti-HIV activity. However, some unfavorable ... -
Multifunctional Banking and Financial Fragility: What Should Banks Do?
(2015-05-22)This dissertation traces the evolution of the U.S. banking system since the 1980s with a specific focus on the role of the relaxation and eventual repeal of Glass-Steagall Act (GSA) on the stability of the financial ... -
The relationship between African American high school students' desire to attend college, their perceived likelihood to attend college and actual college entrollment
(2013)African American students continue to be an underrepresented population in institutions of higher education. This study uses Mickelson’s Attitude-Achievement Paradox to explain the effect of individual and contextual SES, ... -
Light-activated biomacromolecules
(2013)Biomacromolecules, mainly nucleic acids and proteins, are involved in every cellular process and therefore their aberrant level or function is linked with most of the diseases. Controlling these macromolecules using light ... -
Modulation of neuronal ryanodine receptor-mediated calcium signaling by calsenilin
(2013)Calsenilin is calcium (Ca2+) ion Ca2+ binding protein found in the nucleus, plasma membrane, and endoplasmic reticulum of neuronal cells. Calsenilin was first found to interact with two proteins involved in early-onset ... -
Calculating the structure-based phylogenetic relationship of distantly related homologous proteins utilizing maximum likelihood structural alignment combinatorics and a novel structural molecular clock hypothesis
(2013)Dendrograms establish the evolutionary relationships and homology of species, proteins, or genes. Homology modeling, ligand binding, and pharmaceutical testing all depend upon the homology ascertained by dendrograms. ... -
Ab initio computational applications of electronic structure and spectroscopic Properties of bulk Crystalline materials
(2013)Boron-rich compounds and elemental boron have amazing chemical, physical and mechanical properties, but puzzling structures. The uncertain stoichiometric value of foreign elements in boron-rich compounds greatly influences ... -
Interactions between drugs of abuse and HIV protease inhibitors
(2014-07-09)Drug abuse is an escalating problem prevalent in both large metropolitan and rural places and is a major cause of mortality and morbidity all over the world. Drugs of abuse such as morphine and nicotine are consumed by ... -
Synthesis and analysis of siloranes for use as a biomaterial and extended twisted molecular ribbons
(2013)The development of complex organic molecules with industrial potential requires meticulous synthetic methodologies coupled with detailed investigations surrounding their physical properties. This dissertation encompasses ... -
EVASION OF EFFLUX AND ENHANCING BIOAVAILABILITY OF AMPRENAVIR BY PRODRUG DERIVATIZATION
(2013)Millions of people worldwide have been infected with human immunodeficiency (HIV). Highly active antiretroviral therapy (HAART) has substantially improved the clinical management of HIV-1 infection. Inclusion of HIV protease ... -
Paleoseismology and Archaeoseismology along the Southern Dead Sea Transform in Wadi 'Arabah Near the municipality of Aqaba, Jordan
(2013)The southern Wadi ‘Arabah Valley in Jordan provides an ideal location to investigate both the paleoseismology and archaeoseismology of the region because it is situated directly along the active Dead Sea transform, and ... -
To the Forgotten : for orchestra
(2013)To the forgotten is inspired by the process of observing nature and realizing the interrelationship between humanity and nature by the method of self-preservation. I discovered a similar approach toward nature in three ...