RSS 1.02013 UMKC Dissertations - Freely Available Online
This community contains the collections of dissertations submitted electronically to the School of Graduate Studies by doctoral degree candidates at the University of Missouri-Kansas City. The items in this collection are dissertations that are available to the general public.
Items in MOspace are protected by copyright, with all rights reserved, unless otherwise indicated.
Recent Submissions
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Development of Pentablock Copolymer Based Formulations for the Sustained Delivery of Protein Therapeutics in the Treatment of Posterior Segment Ocular Diseases
(2013)We have successfully synthesized pentablock (PB) copolymers comprised of various FDA approved polymer blocks such as polyethylene glycol (PEG), polycaprolactone (PCL), polylactic acid (PLA) and polyglycolic acid (PGA). PB ... -
Novel Transporter Targeted Lipid Ester Prodrugs of Cidofovir and Sustained Release Formulations for Cytomegalovirus Infection
(2013)Cidofovir (CDF) has shown potential in vitro and in vivo antiviral activity against cytomegalovirus (CMV) retinitis. However, low CDF permeability due to its hydrophilic nature limits its effectiveness. Furthermore, ... -
Provider Perceptions of a Mature School-Based Health Center's Effect on Adolescent Health and Wellness: A Case Study
(2015-06-02)School-based health centers (SBHCs) have emerged as a model of care that enhances utilization of health care services for U.S. adolescents. Staffed by interdisciplinary teams, physicians play a largely supervisory role ... -
Transporter-Targeted Prodrug Delivery to Improve Oral Bioavailability of Saquinavir
(2015-05-22)Saquinavir (SQV) is the first antiretroviral protease inhibitor approved by Food and Drug Administration in the United States for the treatment of HIV infection due to its potent anti-HIV activity. However, some unfavorable ... -
The relationship between African American high school students' desire to attend college, their perceived likelihood to attend college and actual college entrollment
(2013)African American students continue to be an underrepresented population in institutions of higher education. This study uses Mickelson’s Attitude-Achievement Paradox to explain the effect of individual and contextual SES, ... -
Light-activated biomacromolecules
(2013)Biomacromolecules, mainly nucleic acids and proteins, are involved in every cellular process and therefore their aberrant level or function is linked with most of the diseases. Controlling these macromolecules using light ... -
Modulation of neuronal ryanodine receptor-mediated calcium signaling by calsenilin
(2013)Calsenilin is calcium (Ca2+) ion Ca2+ binding protein found in the nucleus, plasma membrane, and endoplasmic reticulum of neuronal cells. Calsenilin was first found to interact with two proteins involved in early-onset ... -
Calculating the structure-based phylogenetic relationship of distantly related homologous proteins utilizing maximum likelihood structural alignment combinatorics and a novel structural molecular clock hypothesis
(2013)Dendrograms establish the evolutionary relationships and homology of species, proteins, or genes. Homology modeling, ligand binding, and pharmaceutical testing all depend upon the homology ascertained by dendrograms. ... -
Ab initio computational applications of electronic structure and spectroscopic Properties of bulk Crystalline materials
(2013)Boron-rich compounds and elemental boron have amazing chemical, physical and mechanical properties, but puzzling structures. The uncertain stoichiometric value of foreign elements in boron-rich compounds greatly influences ... -
Interactions between drugs of abuse and HIV protease inhibitors
(2014-07-09)Drug abuse is an escalating problem prevalent in both large metropolitan and rural places and is a major cause of mortality and morbidity all over the world. Drugs of abuse such as morphine and nicotine are consumed by ... -
Synthesis and analysis of siloranes for use as a biomaterial and extended twisted molecular ribbons
(2013)The development of complex organic molecules with industrial potential requires meticulous synthetic methodologies coupled with detailed investigations surrounding their physical properties. This dissertation encompasses ... -
EVASION OF EFFLUX AND ENHANCING BIOAVAILABILITY OF AMPRENAVIR BY PRODRUG DERIVATIZATION
(2013)Millions of people worldwide have been infected with human immunodeficiency (HIV). Highly active antiretroviral therapy (HAART) has substantially improved the clinical management of HIV-1 infection. Inclusion of HIV protease ... -
Paleoseismology and Archaeoseismology along the Southern Dead Sea Transform in Wadi 'Arabah Near the municipality of Aqaba, Jordan
(2013)The southern Wadi ‘Arabah Valley in Jordan provides an ideal location to investigate both the paleoseismology and archaeoseismology of the region because it is situated directly along the active Dead Sea transform, and ... -
To the Forgotten : for orchestra
(2013)To the forgotten is inspired by the process of observing nature and realizing the interrelationship between humanity and nature by the method of self-preservation. I discovered a similar approach toward nature in three ... -
Energy and Data Conversion Circuits for Low Power Sensory Systems
(2013)This dissertation focuses on the problem of increasing the lifetime of wireless sensors. This problem is addressed from two different angles: energy harvesting and data compression. Energy harvesting enables a sensor to ... -
The Risk of Recidivism and the Positive Achievement Change Tool Pre-Screen (PACT-PS): An Initial Validation and Basic Program Implementation Evaluation
(2014-04-02)The juvenile justice system has long been challenged to provide security for communities, while also providing treatment and sanctioning youthful offenders. This task includes the process of determining which offenders ... -
HIV-1 gp120 and Methamphetamine-mediated Induction of Proinflammatory Cytokines/chemokines and Oxidative Stress in Astrocytes: Implications in Neuroinflammation
(2014-04-02)HIV associated neurocognitive disorder (HAND) remains a major concern for patients infected with HIV. The viral envelope protein, gp120 has been extensively studied and some of its neurotoxic effects are due to the increased ... -
A Post-Keynesian/Structuralist Strategy for Economic Development
(2014-04-01)There are two distinct traditions that have widely different views on the fundamental problem of economic development. This dissertation makes a contribution to the tradition known as the Scarcity in the Midst of Plenty ... -
Teacher Reported Preparedness: A Study of One Midwest Metropolitan School District
(2013)The ultimate purpose of school lies in the success and achievement of its students. Therefore, efforts must be made to continuously improve achievement for every student. What the teacher knows and can do in the classroom ... -
The Effects of the Classroom Schedule and Teacher Beliefs on Head Start Teacher-Child Interactions
(2013)Time can be examined from several viewpoints in the early childhood classroom: wasted wait time; instruction which is undifferentiated or not on the child’s cognitivelevel, missing the child’s target learning needs; the ...