Fetal exposure to low but not high doses of Bisphenol A (BPA) increases abdominal fat, impairs glucose tolerance and alters serum hormones in male mice: evidence for non-monotonic dose-response relationships
Metadata[+] Show full item record
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Bisphenol A (BPA) is a ubiquitous contaminant with estrogenic and other hormonal activities. A criticism of many experimental studies is the lack of examination of a wide does range. We fed pregnant CD-1 mice BPA at doses ranging from 5-50,000 μg/kg/day, spanning 10-fold below the reference dose to 10-fold above the no adverse effect level (NOAEL). At doses below the NOAEL we observed numerous significant effects in adult male offspring: an increase in abdominal adipocyte mass and adipocyte hyperplasia, an increase in liver weight, an increase in leptin and insulin and a decrease in adiponectin in serum, and a decrease in glucose tolerance. For all of these outcomes non-monotonic dose-response relationships were observed, and for no outcome was there a significant effect of the highest BPA dose. a 0.1-μg/kg/day does of DES (the low-dose estrogen positive control) resulted in similar effects for some but not all low-dose BPA outcomes.
Access is limited to the campuses of the University of Missouri.