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dc.contributor.advisorvom Saal, Frederick S.eng
dc.contributor.authorAngle, Brittany M.eng
dc.date.issued2012eng
dc.date.submitted2012 Falleng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on March 18, 2013).eng
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.eng
dc.descriptionThesis advisor: Fred S. vom Saaleng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionM.A. University of Missouri-Columbia 2012.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Biological sciences.eng
dc.description"December 2012"eng
dc.description.abstract[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Bisphenol A (BPA) is a ubiquitous contaminant with estrogenic and other hormonal activities. A criticism of many experimental studies is the lack of examination of a wide does range. We fed pregnant CD-1 mice BPA at doses ranging from 5-50,000 μg/kg/day, spanning 10-fold below the reference dose to 10-fold above the no adverse effect level (NOAEL). At doses below the NOAEL we observed numerous significant effects in adult male offspring: an increase in abdominal adipocyte mass and adipocyte hyperplasia, an increase in liver weight, an increase in leptin and insulin and a decrease in adiponectin in serum, and a decrease in glucose tolerance. For all of these outcomes non-monotonic dose-response relationships were observed, and for no outcome was there a significant effect of the highest BPA dose. a 0.1-μg/kg/day does of DES (the low-dose estrogen positive control) resulted in similar effects for some but not all low-dose BPA outcomes.eng
dc.format.extentv, 45 pageseng
dc.identifier.urihttp://hdl.handle.net/10355/33238
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcollectionUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsAccess is limited to the campuses of the University of Missouri.eng
dc.subjectBisphenol Aeng
dc.subjecthormonal activitieseng
dc.subjectabdominal adipocyteeng
dc.titleFetal exposure to low but not high doses of Bisphenol A (BPA) increases abdominal fat, impairs glucose tolerance and alters serum hormones in male mice: evidence for non-monotonic dose-response relationshipseng
dc.typeThesiseng
thesis.degree.disciplineBiological sciences (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.A.eng


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