What is the best regimen for newly diagnosed hypertension?

Abstract

Low-dose thiazide diuretics (eg, hydrochlorothiazide 12.5 to 25 mg/d) are the best first-line pharmacotherapy for treating uncomplicated hypertension(strength of recommendation [SOR]: A, based on randomized trials [RCTs] and 1 meta-analysis). Alternate first-line agents include angiotensinconverting enzyme (ACE) inhibitors, beta blockers, and calcium channel blockers (SOR: A, based on RCTs).