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Recent Submissions

  • Treatment of Herpes Zoster 

    Holten, Keith B.; Britigan, Denise H. (Family Physicians Inquiries Network, 2006-03)
    Resolution of acute pain related to herpes zoster is accelerated with any of the following: oral acyclovir (Zovirax) 800 mg five times daily for seven days; valacyclovir (Valtrex) 1,000 mg three times daily for seven days; ...
  • Treatments for Chronic Prostatitis 

    Meza, James; Alam, Shah; Martin, Sandra I. (Family Physicians Inquiries Network, 2006-08)
    Because the etiology of chronic nonbacterial prostatitis is unknown, a variety of treatments have been proposed. The best- designed, largest clinical trials have not found the most commonly used therapies (i.e., alpha ...
  • Risks and Benefits of Combination Contraceptives 

    Roederer, Mary W.; Blackwell, Jean (Family Physicians Inquiries Network, 2006-12)
    The risks of using oral combination contraceptives include: a three- to sixfold increase in the incidence of venous thromboembolism (VTE) apparent by the fourth month of use and highest between six and 12 months of use; a ...
  • Vaginal Misoprostol for Cervical Ripening in Term Pregnancy 

    Weaver, Sally P.; Cook, Jessica; Nashelsky, Joan (Family Physicians Inquiries Network, 2006-02)
    Low-dose (25 mcg) intravaginal misoprostol appears to be safe and effective for cervical ripening in term pregnancy for patients without a history of cesarean section. Compared with other cervical ripening methods, misoprostol ...
  • Urine Dipstick for Diagnosing Urinary Tract Infection 

    Wright, Olivia Rae; Safranek, Sarah (Family Physicians Inquiries Network, 2006-01)
    The sensitivity and specificity of the urine dipstick varies somewhat with the setting and population, as does its recommended interpretation. In low-risk patients with a low pretest probability of UTI, the urine dipstick ...
  • Glucosamine and Chondroitin for Osteoarthritis 

    Fox, Beth Anne; Schmitz, Evan D.; Wallace, Rick (Family Physicians Inquiries Network, 2006-04)
    Glucosamine reduces pain and improves function in patients with knee or hip osteoarthritis. (Strength of recommendation: B, based on systematic reviews and a meta-analysis) Glucosamine may be beneficial in other forms of ...
  • Warfarin for Prevention of Ischemic Stroke Recurrence? 

    Lo, Vincent; Noviasky, John; Nashelsky, Joan (Family Physicians Inquiries Network, 2006-06)
    There is no evidence that anticoagulation with warfarin, initiated after a non- cardioembolic ischemic stroke, significantly reduces stroke recurrence. Furthermore, anticoagulation significantly increases the risk of fatal ...
  • A1C Testing in the Diagnosis of Diabetes Mellitus 

    Lee, Tae Joon; Safranek, Sarah (Family Physicians Inquiries Network, 2006-07)
    A1C testing is highly specific compared with a two-hour oral glucose tolerance test (OGTT) or a fasting plasma glucose test. However, because A1C testing is not sensitive enough to rule out diabetes if levels are normal, ...
  • Psychosocial Interventions Delivered by Primary Care Physicians to Patients with Depression 

    Clark, Molly S.; Smith, Patrick O.; Payne, Thomas J.; Collins, Linda J. (Family Physicians Inquiries Network, 2006-11)
    Few high-quality studies have been conducted examining the effectiveness of psychosocial interventions performed by primary care physicians for patients with major depression. Two randomized controlled clinical trials ...
  • Who should receive vertebroplasty? 

    Satre, Thomas J.; Mackler, Leslie (Family Physicians Inquiries Network, 2006-07)
    Percutaneous vertebroplasty has been used to treat aggressive vertebral hemangiomas, osteoporotic vertebral compression fractures, and vertebral lesions from metastatic disease or myeloma. Consider it for patients with ...
  • Which vaccinations are indicated after splenectomy? 

    Webb, Charles W.; Crowell, Karen (Family Physicians Inquiries Network, 2006-08)
    Immunization against encapsulated bacterial pathogens decreases the incidence of post- splenectomy sepsis. Pneumococcal, meningococcal, and Haemophilus influenzae (Hib) vaccinations are indicated for patients after ...
  • Which medications can be split without compromising efficacy and safety? 

    Noviasky, John; Lo, Vincent; Luft, Diane Davis (Family Physicians Inquiries Network, 2006-08)
    Split tablets of lisinopril are as effective as whole tablets of the same dose for hypertension (SOR: B, based on small randomized crossover study). Similarly, split tablets of atorvastatin, lovastatin, and simvastatin ...
  • When should a child with an undescended testis be referred to a urologist? 

    Kelsberg, Gary; Bishop, Rachel; Morton, Jacquelyn R. (Family Physicians Inquiries Network, 2006-04)
    Infants with an undescended testis should be referred between ages 6 and 15 months, since almost all who experience spontaneous descent do so by 6 months (strength of recommendation [SOR]: A, extrapolation from cohort ...
  • When should we screen children for hyperlipidemia? 

    Misicko, Nancy E.; St. Anna, Leilani (Family Physicians Inquiries Network, 2006-08)
    Children should be screened for hyperlipidemia when there is a history of familial hypercholesterolemia (strength of recommendation [SOR]: C). No clear evidence supports screening all children or just those with family ...
  • When are empiric antibiotics appropriate for urinary tract infection symptoms? 

    DeAlleaume, Lauren; Tweed, Elizabeth M. (Family Physicians Inquiries Network, 2006-04)
    Healthy, nonpregnant women presenting with the triad of frequency, dysuria, and no vaginal symptoms have about a 96% chance of having an urinary tract infection (UTI) (positive likelihood ratio [LR+]=24.6). Since no ...
  • When should COX-2 selective NSAIDs be used for osteoarthritis and rheumatoid arthritis? 

    Lo, Vincent; Meadows, Susan E. (Family Physicians Inquiries Network, 2006-03)
    Cyclo-oxygenase-2 (COX-2) selective nonsteroidal anti-inflammatory drugs (NSAIDs) are as effective as acetaminophen and nonselective NSAIDs in treating of osteoarthritis, and are equally effective in reducing pain and ...
  • When are antibiotics indicated for acute COPD exacerbations? 

    Balser, Emily; Neher, Jon O.; Safranek, Sarah (Family Physicians Inquiries Network, 2006-12)
    Antibiotics (including those given orally) reduce mortality and treatment failures for hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease (COPD) (strength of recommendation [SOR]: A, ...
  • What is the best way to treat tinea cruris? 

    Nadalo, Dana; Montoya, Cathy C. (Family Physicians Inquiries Network, 2006-03)
    After clinical diagnosis and microscopic confirmation, tinea cruris is best treated with a topical allylamine or an azole antifungal (strength of recommendation: A, based on multiple randomized controlled trials [RCTs]). ...
  • What is the best way to manage GERD symptoms in the elderly? 

    Bacak, Brian S.; Patel, Mihir; Tweed, Elizabeth M. (Family Physicians Inquiries Network, 2006-03)
    No evidence supports one method over another in managing uncomplicated gastroesophageal reflux disease (GERD) for patients aged >65 years. For those with endoscopically documented esophagitis, proton pump inhibitors (PPIs) ...
  • What is the best way to diagnose a suspected rotator cuff tear? 

    Diehr, Sabina; Ison, David; Jamieson, Barbara (Family Physicians Inquiries Network, 2006-07)
    The evaluation of a suspected rotator cuff tear should start with a history and a clinical exam of the shoulder (strength of recommendation [SOR]: B, based on a systematic review of cohort studies). Three clinical ...

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