Is long-term use of zolpidem for the treatment of insomnia habit forming?
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Use of zolpidem for 6 to 12 months does not result in tolerance, escalation of dosing, or rebound insomnia (SOR: A, multiple RCTs). Zolpidem dependence or abuse is rare but has been reported, primarily in patients who have psychiatric or substance use disorders (SOR: C, case reports).
Evidence Based Practice 16(3): 14.