What medications are effective in the treatment of anorexia/cachexia associated with advanced cancer?
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Megestrol acetate is associated with improved appetite and weight gain in cancer-related anorexia-cachexia syndrome (CACS), but has not been shown to improve survival (SOR: A, meta-analysis). Thalidomide treatment results in less weight loss, but again any impact on survival is unknown (SOR: B, RCT). Eicosapentaenoic acid is not effective (SOR: B, meta-analysis of small RCTs).
Evidence Based Practice 16(3): 09-10.