University of Missouri-Kansas City: Recent submissions
Now showing items 21-40 of 3440
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Exploring Multivalency and Chemical Modifications in the Development of Anti-PD-L1 Peptide Inhibitors for Cancer Immunotherapy
(2023)The PD-1/PD-L1 immune checkpoint axis is one of the most common pathways exploited by cancers to evade immune surveillance. Many cancers overexpress PD-L1 (programmed cell death ligand 1) on their surface through which ... -
Discovery of IKBKE and CD24 siRNAs for the Treatment of Triple-Negative Breast Cancer
(2023)Triple-negative breast cancer (TNBC) represents approximately 10-20% of all newly diagnosed breast cancers and is classified as a subtype with the absence of ER, PR, and HER2 expression. TNBC displays high aggressiveness, ... -
Cross-cultural musical encounters: Muslim Mediterranean in the Enlightenment imagination
(2023)The rise of Enlightenment thinking during the seventeenth and eighteenth centuries prompted many thinkers to search for new knowledge in varied ways. This shift motivated travelers to journey to places farther outside of ... -
Three essays on Platform Capitalism and its alternative
(2023)This dissertation delves into the intricate landscape of platform capitalism and its multifaceted relationship with labor dynamics, bringing forth a nuanced understanding of the evolving economic terrain. The first ... -
“It has already exposed you to some very impertinent remarks": Intertextual regulation of women from the early British novel to the twenty-first century screen
(2023)This interdisciplinary dissertation examines twenty-first century film adaptations of Jane Austen’s work as intertextual, intermedial products with roots in the early-British novel. Rather than being direct offspring of ... -
Investigation of Process–Structure–Property Correlations for Plasma-Enhanced Chemical Vapor Deposited Complex Disordered Solids: Towards Data-Driven Computational Materials Design
(2023)Complex disordered solids, characterized by multicomponent, multiphase, sub-structured configurations, coupled with a lack of long-range order, represent an application-rich class of materials, exhibiting a vast number of ... -
Direct Extrusion Printability of Internal Phase Nanostructured Hydrogels
(2023)An experimental study in open-air direct extrusion of fatty acid-based ternary system gels is presented. When promising self-supporting mechanical abilities are observed in some pure ternary experiments, photoinitiators ... -
Investigation and development of wideband antenna gain enhancement techniques
(2023)The far-field gain of an antenna relies on its physical dimensions, often posing a challenge for achieving higher gain without increasing size. We address this issue by exploring innovative design strategies to enhance the ... -
Targeting Extracellular Matrix Using siRNA for the Treatment of Liver Fibrosis and Pancreatic Cancer
(2023)The objective of this dissertation is to develop peptide-based siRNA delivery systems for the treatment of liver fibrosis and pancreatic ductal adenocarcinoma (PDAC). We recently discovered that silencing the poly (rC) ... -
MITIGATING ANTIBIOTIC-RESISTANT PATHOGENS: A MULTIFACETED STRATEGY FOR NOVEL ANTIBACTERIAL DRUG DEVELOPMENT AND COMPREHENSIVE LCMS/MS APPLICATIONS FOR DIVERSE THERAPEUTIC ADVANCEMENTS
(2023)In response to the escalating threat of antimicrobial resistance, our study adopted a multifaceted strategy to combat antibiotic-resistant pathogens. The initial phase involved the screening of the GSK TB box set against ... -
IDENTIFICATION AND ASSESSMENT OF PEPTIDES AND SINGLE DOMAIN ANTIBODIES FOR CANCER THERAPY
(2023)The discovery of immune checkpoint inhibitors has revolutionized cancer therapy. These immune checkpoint inhibitors suppress tumor growth by immune checkpoint blockade. This approach involves blocking inhibitory immune ... -
A universal approach to stabilize water-oil interface via surfactant self-assembly
(2023)Liquid-liquid interfaces represent an advantageous setting for the confinement, manipulation, and controlled assembly of colloids. Stabilizing liquid-liquid interfaces, whether between miscible or immiscible liquids, is ... -
Beyond the Abyss: American Gaslight and Popular Literature
(2023)The mainstream feminist movement in the United States has struggled to include women of color and marginalized women. However, two constants emerge from the work of both white feminists and feminists of color: first, writing ... -
Investigation of Electrically Tunable Diode-based Nonlinear Transmission Lines as Pulse Shaping Networks for Microwave Systems at Megawatt Peak Powers
(2023)The pulsed power community is actively concentrating on the miniaturization of high-power microwave (HPM) systems, driven by the growing demand for applications on oceanic vessels, satellites, and unmanned aerial vehicles. ... -
How Spirituality and Fatigue Interact to Affect Quality of Life in Patients with Metastatic Breast Cancer
(2023)The cognitive theory of stress and coping by Lazarus and Folkman can explain how individuals cope with a stressful chronic illness, specifically metastatic breast cancer (MBC). If an individual appraises their MBC as ... -
Confounding Changes: Collected Poems
(2023)ABSTRACT This is a collection of poems addressing how to live as a problem solver in a dangerous world. I am aware of two planet-sized existential crises—climate and nuclear war. I trained as an environmental educator in ... -
Forgive Me, Father, For I Have Sinned: The Dramatic Potency of Confession on the Early Modern English Shakespearean Stage
(2023)Though forcefully absent in its traditional practice by political and religious reformation, evidence of confession in early modern English drama remained and became representative of an exchange of power between dramatic ... -
Hell Hath No Fury, Book One of the Divine Dramedy
(2023)This thesis is the first and partial second draft of my fiction novel which I have written throughout my time as a graduate student at the University of Missouri-Kansas City Master of Fine Arts program. This work tells the ... -
Turkic Educators and Students Breaking Their Silence: An Oral History of a Tangled Web of Political Power
(2023)The social genocide of the Hizmet people by the Erdoğan regime has left an indelible mark on Turkic educators and students worldwide. The practice of genocide as a form of political control is steeped in the history of the ... -
Spirituality in American Muslim Marriages: An Investigation of Marital Sanctification, Spiritual Intimacy and Emotional Intimacy
(2023)The current study investigated how spiritual intimacy and emotional intimacy potentially mediated the impact of marital sanctification on positive and negative marital quality. Moreover, the present study examined if gender ...