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dc.contributor.advisorPeterson, Catherine Anneng
dc.contributor.authorBelenchia, Anthonyeng
dc.date.issued2012eng
dc.date.submitted2012 Springeng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on May 29, 2013).eng
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.eng
dc.descriptionThesis advisor: Dr. Catherine A. Petersoneng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionM.S. University of Missouri--Columbia 2012.eng
dc.description"May 2012"eng
dc.description.abstractPurpose: The primary aim of this study was to determine the effects of improving vitamin D status through daily supplementation of 4000 IU would improve markers of glucose metabolism and inflammation in obese adolescents. Methods: (age=14.2[plus or minus]2.6 years; BMI=39.2[plus or minus]5.9) were recruited from the University of Missouri-Adolescent Diabetes and Obesity clinic and were randomized to receive either placebo or vit D3 (4000 IU/day) as part of their standard treatment for 6 months. Results: After six months, subjects supplemented with vitamin D3 had significant changes in serum 25-hydroxyvitamin D concentrations (19.4 vs 3.8 ng/ml for placebo; P<0.001), HOMA-IR (-1.63 vs +0.27 for placebo; P=0.026) and QUICKI (+0.016 vs -0.004; P=.016). Additionally, the leptin:adiponectin ratio was reduced in vitamin D group versus placebo (-1.41 vs +0.10 P=0.45). No significant changes from baseline in inflammatory markers were detected between groups. Conclusions: Correcting the poor vitamin D status associated with obesity may be an effective and inexpensive adjuvant to treatment of obesity-related metabolic complications.eng
dc.format.extentvi, 121 pageseng
dc.identifier.urihttp://hdl.handle.net/10355/35395
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcollectionUniversity of Missouri-Columbia. Graduate School. Theses and Dissertationseng
dc.rightsOpenAccess.eng
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
dc.subjectvitamin supplementeng
dc.subjectobesityeng
dc.subjectglucose metabolismeng
dc.subjectadolescent populationeng
dc.titleThe effects of high dose vitamin D supplementation on glucose metabolism and inflammation in obese adolescentseng
dc.typeThesiseng
thesis.degree.disciplineNutrition area program (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.S.eng


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