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    What is the role of combination therapy (insulin plus oral medication) in type 2 diabetes?

    Eskesen, Staci
    Kelsberg, Gary
    Hitchcock, Kristin
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    [PDF] WhatRoleCombinationTherapyType2.pdf (130.0Kb)
    Date
    2006
    Format
    Article
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    Abstract
    Combination therapy using insulin plus metformin (Glucophage), a sulfonylurea, or both produces glycemic control comparable with using insulin alone, but there is less weight gain when metformin is used (strength of recommendation [SOR]: B, based on systematic review of randomized controlled trials [RCTs] with some heterogeneity). Combination therapy using insulin and pioglitazone (Actos) reduces glycosylated hemoglobin (HbA1c) more than either insulin alone or adding pioglitazone to a sulfonylurea, but results in more weight gain (SOR: A, based on RCT).
    URI
    http://hdl.handle.net/10355/3540
    Part of
    Journal of family practice, 55, no. 11 (November 2006): 998-1000
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
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    • Clinical Inquiries, 2006

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