What is the role of combination therapy (insulin plus oral medication) in type 2 diabetes?

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What is the role of combination therapy (insulin plus oral medication) in type 2 diabetes?

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Title: What is the role of combination therapy (insulin plus oral medication) in type 2 diabetes?
Author: Eskesen, Staci; Kelsberg, Gary; Hitchcock, Kristin
Keywords: nocturnal hypoglycemic events
weight gain
glycemic control
Date: 2006-11
Publisher: Family Physicians Inquiries Network
Citation: Journal of Family Practice, 55(11) 2006: 998-1000.
Abstract: Combination therapy using insulin plus metformin (Glucophage), a sulfonylurea, or both produces glycemic control comparable with using insulin alone, but there is less weight gain when metformin is used (strength of recommendation [SOR]: B, based on systematic review of randomized controlled trials [RCTs] with some heterogeneity). Combination therapy using insulin and pioglitazone (Actos) reduces glycosylated hemoglobin (HbA1c) more than either insulin alone or adding pioglitazone to a sulfonylurea, but results in more weight gain (SOR: A, based on RCT).
URI: http://hdl.handle.net/10355/3540

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