What is the role of herpes virus serology in sexually transmitted disease screening?
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Screening for herpes simplex virus type 2 (HSV-2) infection with antibody testing is not indicated for asymptomatic adults (strength of recommendation [SOR]: B, prevalence studies and predictive value of testing). Screening with serology testing is not indicated for asymptomatic pregnant women (SOR: B, 1 cohort study). You may consider offering testing to asymptomatic patients with an HSV-positive partner, patients with HIV infection, and those with current or recent sexually transmitted infection or high-risk behavior (SOR: C, expert opinion and 1 case control study with extrapolation of results).
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