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dc.contributor.advisorLever, Teresa E.eng
dc.contributor.authorCollins, Michelle Patriceeng
dc.date.issued2012eng
dc.date.submitted2012 Springeng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on May 31, 2013).eng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionThesis advisor: Dr. Teresa E. Levereng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionM.H.S. University of Missouri-Columbia 2012.eng
dc.description"May 2012"eng
dc.description.abstract[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Previous work in our lab has established the SOD1-G93A transgenic mouse as a suitable model for dysphagia (swallowing impairment) in amyotrophic lateral sclerosis (ALS). This strain has significantly impaired lick and mastication rates at 8 weeks of age, which is the earliest time point tested to date. We have extended this previous work by testing mice post-weaning at 3, 5, and 7 weeks of age. At each time point, SOD1-G93A transgenic mice demonstrated a significantly slower lick rate compared with age-matched, nontransgenic controls (p<0.05). No group differences in mastication rate were identified. This early-onset impairment in lick rate suggests that SOD1-G93A transgenic mice may be a model of bulbar-onset rather than spinal-onset ALS. Therefore, the SOD1-G93A transgenic mouse may be uniquely suitable to studying the onset and progression of dysphagia in humans with bulbar-onset ALS, which occurs in [about]30% of cases.eng
dc.format.extentv, 27 pageseng
dc.identifier.urihttp://hdl.handle.net/10355/35433
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsAccess is limited to the campuses of the University of Missouri.eng
dc.subjectbulbar-onset ALSeng
dc.subjectspinal-onset ALSeng
dc.subjectlick rateeng
dc.subjectdysphagiaeng
dc.titleIdentification of dysphagia in a transgenic mouse model of amyotrophic lateral sclerosiseng
dc.typeThesiseng
thesis.degree.disciplineCommunication science and disorders (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.H.S.eng


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