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dc.contributor.advisorLever, Teresa E.eng
dc.contributor.authorPinnegar, Abbie Joleneeng
dc.date.issued2012eng
dc.date.submitted2012 Springeng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on May 31, 2013).eng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf fileeng
dc.descriptionThesis advisor: Dr. Teresa E. Levereng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionM.H.S. University of Missouri-Columbia 2012.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- communication science & disorders.eng
dc.description"May 2012"eng
dc.description.abstract[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Unspecified swallowing impairment (dysphagia) was recently reported in dogs with degenerative myelopathy (DM), a proposed disease model of amyotrophic lateral sclerosis (ALS). The purpose of our study was to establish a clinicopathological correlation of dysphagia in canine DM. We investigated the brainstem nuclei involved in swallowing in DM and control dogs. Samples were procured from the College of Veterinary Medicine, University of Missouri. Subtle evidence of neurodegeneration within each of the brainstem nuclei involved in swallowing was identified in DM samples using hematoxylin & eosin staining. Immunohistochemical methods are currently underway to substantiate this finding. Given that virtually all humans with ALS develop dysphagia, characterization of swallowing impairment is imperative to validate canine DM as a bona fide animal model of ALS. This line of research has the potential to benefit both people and dogs with dysphagia related to ALS and other diseases that cause dysphagia.eng
dc.format.extentv, 36 pageseng
dc.identifier.urihttp://hdl.handle.net/10355/35437
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcollectionUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsAccess is limited to the campuses of the University of Missouri.eng
dc.subjectdysphagiaeng
dc.subjectbrainstem nucleieng
dc.subjectneurodegenerationeng
dc.titleInvestigating canine degenerative myelopathy as a disease model of amyotrophic lateral sclerosis for histopathological evidence of dysphagiaeng
dc.typeThesiseng
thesis.degree.disciplineCommunication science and disorders (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.H.S.eng


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