Should you test or treat pregnant women with a history of pregnancy-related VTE?
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No high-quality evidence supports testing for thrombophilia in pregnant patients who have experienced venous thromboembolism (VTE) in a previous pregnancy. Antepartum and postpartum anticoagulation with LMWH produces lower rates of VTE in patients with a prior history of VTE in pregnancy. Pregnant women with a prior history of VTE who are not treated with anticoagulation have about a 5% risk of antepartum or postpartum VTE. Expert opinion recommends graduated compression stockings.
Evidence Based Practice 16(6): 01-02.