What is the best treatment for mild to moderate acne?
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For mild comedonal acne, monotherapy with topical retinoids is the treatment of choice (strength of recommendation [SOR]: A). For moderate comedonal and mild to moderate papulopustular acne, combination therapy with either benzoyl peroxide or topical retinoids (adapalene [Differin], tazarotene [Tazorac], tretinoin [Retin-A]) plus topical antibiotics (erythromycin or clindamycin) is proven most effective (SOR: A). Six to eight weeks should be allowed for most treatments to work before altering the regimen (SOR: A).
Journal of Family Practice, 55(11) 2006: 994+.