Which medications can be split without compromising efficacy and safety?

Abstract

Split tablets of lisinopril are as effective as whole tablets of the same dose for hypertension (SOR: B, based on small randomized crossover study). Similarly, split tablets of atorvastatin, lovastatin, and simvastatin are no less effective for lowering cholesterol (SOR: B, based on retrospective cohort studies). Extended-release, entericcoated, or tablets that cannot be split accurately are not appropriate for splitting (SOR: C, based on observational studies); the accuracy of splitting also depends on device used and user skill (SOR: C, based on observational study).