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Recent Submissions

  • Best Alternatives to Statins for Treating Hyperlipidemia 

    Bouknight, Patricia; Mackler, Leslie; Heffington, Mark (Family Physicians Inquiries Network, 2007-10)
    Most alternatives to statin therapy reduce cholesterol levels but do not consistently demonstrate a reduction in cardiac-related and all-cause mortality in patients with or without coronary heart disease (CHD). Fibrates ...
  • Which UTI therapies are safe and effective during breastfeeding? 

    Kaiser, Jessica; McPherson, Vanessa; Kaufmann, Leonora (Family Physicians Inquiries Network, 2007-03)
    Trimethoprim/sulfamethoxazole (TMP/SM X) has a high success rate in eradicating bacteriuria for women with urinary tract infection and is compatible with breastfeeding (strength of recommendation: C, based on extrapolation ...
  • Angiotensin Blockade in Patients with Diabetic Nephropathy 

    Jimenez, Julio; Safranek, Sarah (Family Physicians Inquiries Network, 2007-08)
    When used to delay the progression of early nephropathy in patients with type 2 diabetes mellitus, angiotensin receptor blockers (ARBs) are not superior to angiotensin-converting enzyme (ACE) inhibitors. (Strength of ...
  • Glycemic Control in Patients with Type 2 Diabetes 

    Glendenning, Charles; Kaufmann, Lee (Family Physicians Inquiries Network, 2007-04)
    There is no clearly superior oral agent for glycemic control in patients with type 2 diabetes. (Strength of Recommendation [SOR]: C) Metformin (Glucophage) has shown additional benefit when compared with other treatments ...
  • Evaluation of Apparent Life-Threatening Events in Infants 

    Warren, Johanna; Biagioli, Frances E.; Hamilton, Andrew (Family Physicians Inquiries Network, 2007-07)
    A comprehensive, detailed history and physical examination with pulse oximetry and nondilated funduscopy (to look for traumatic retinal hemorrhage) helps to determine the underlying etiology of an apparent life-threatening ...
  • Treatment of Acute Sciatica 

    Markova, Tsveti; Dhillon, Baldev Singh; Martin, Sandra I. (Family Physicians Inquiries Network, 2007-01)
    In patients with acute sciatica, bed rest and advice to stay active have similar outcomes on their functional status and perceived improvement. (Strength of Recommendation [SOR]: A) Spinal manipulation increases improvement ...
  • Treatment of Impetigo 

    Price, David; Betancourt, Victoria; Kaufman, Leonora (Family Physicians Inquiries Network, 2007-03)
    Topical mupirocin (Bactroban) and fusidic acid (not available in the United States) are more effective than placebo and at least as effective as oral antibiotics for the treatment of limited impetigo, and are better ...
  • Monitoring Therapy for Patients with Alzheimer's Disease 

    Raetz, Jaqueline; Luft, Eric v.d. (Eric von der), 1952- (Family Physicians Inquiries Network, 2007-06)
    Patients with Alzheimer's disease who undergo treatment of any kind should be monitored eight weeks after initiation of therapy and at least every six months thereafter. (Strength of Recommendation: C, based on expert ...
  • Metformin Therapy and Diabetes Prevention in Adolescents Who Are Obese 

    Rodriguez, Jose E.; Shearer, Barbara (Family Physicians Inquiries Network, 2007-11)
    No studies have addressed the question of whether metformin reduces development of diabetes among adolescents who are obese. Metformin treatment in adolescents who are obese can modestly reduce risk factors for type 2 ...
  • Which Lipoprotein Measurements Are Clinically Useful? 

    Pejic, Rade N.; Jamieson, Barbara (Family Physicians Inquiries Network, 2007-02)
    Emerging lipid risk factors for cardiovascular disease include lipoprotein remnants, lipoprotein (a), small LDL particles, HDL subspecies, apolipoprotein B, apolipoprotein A-I, and oxidized LDL. Measurement of these levels ...
  • Group Medical Visits for the Management of Chronic Pain 

    Gaynor, Christopher H.; Vincent, E. Chris; Safranek, Sarah (Family Physicians Inquiries Network, 2007-12)
    Improvements of possible practical significance were seen for various clinical measures in studies of group treatment sessions for patients with back pain, arthritis, and rheumatic disease. However, studies on group treatment ...
  • Which tool is most useful in diagnosing bipolar disorder in children? 

    Stephens, Mary Maniscalco; Bajaj, Jaya; Wallace, Rick (Family Physicians Inquiries Network, 2007-10)
    No single, well-validated screening instrument for clinical diagnosis of bipolar disorder in children exists. That said, the Kiddie Schedule for Affective Disorders and Schizophrenia (KSADS), a semi-structured interview, ...
  • Which tests are the most useful for diagnosing PID? 

    Blenning, Carol E.; Muench, John; Judkins, Dolores Zegar (Family Physicians Inquiries Network, 2007-03)
    No single test has adequate sensitivity and specificity to reliably identify pelvic inflammatory disease (PID) and thus help to spare women serious sequelae, including infertility (strength of recommendation [SOR]: B, ...
  • Which technique for removing nevi is least scarring? 

    Fisher, Michael; Vines, Hattie H. (Family Physicians Inquiries Network, 2007-09)
    A shave biopsy with a razor blade or #15 scalpel is the best approach for a facial nevus, assuming malignancy is not suspected. The resulting scar is usually flat, smaller than the lesion, has no suture lines, and—if ...
  • Which patients with suspected exposure to pertussis should receive prophylaxis? 

    Elliott, Marguerite; Couchene, Elizabeth; Luft, Diane Davis (Family Physicians Inquiries Network, 2007-05)
    Only high-risk close contacts of known cases should receive prophylactic antibiotics, according to the Centers for Disease Control and Prevention (CDC). The CDC defines high-risk as (1) infants who are <12 months, (2) those ...
  • Which oral antifungal is best for toenail onychomycosis? 

    Hinojosa, Jose R.; Hitchcock, Kristin (Family Physicians Inquiries Network, 2007-07)
    Terbinafine, 250 mg taken daily for 12 weeks, is the best regimen for toenail onychomycosis due to better clinical and mycologic cure rates, tolerability, and cost effectiveness (strength of recommendation [SOR]: A, ...
  • Which nondrug alternatives can help with insomnia? 

    Whitworth, James D.; Crownover, Brian K.; Nichols, William (Family Physicians Inquiries Network, 2007-10)
    Cognitive behavioral therapy (CBT) interventions—particularly stimulus control and sleep hygiene—are well-validated, effective treatments for chronic insomnia that are equivalent or superior to pharmacological interventions ...
  • Which lifestyle interventions effectively lower LDL cholesterol? 

    Powers, Elizabeth; Saultz, John W.; Hamilton, Andrew (Family Physicians Inquiries Network, 2007-06)
    Counseling, weight loss, exercise, and drinking alcohol all effectively lower low- density lipoprotein cholesterol (LDL-C). Specifically, one to 2 daily drinks of alcohol lowers L DL-C, if consumed regularly for more than ...
  • Which diuretics are safe and effective for patients with a sulfa allergy? 

    Healy, Ron; Jankowski, Terry Ann, 1951- (Family Physicians Inquiries Network, 2007-06)
    Diuretics that do not contain a sulfonamide group (eg, amiloride hydrochloride, eplerenone, ethacrynic acid, spironolactone, and triamterene) are safe for patients with an allergy to sulfa. The evidence is contra-dictory ...
  • When should you treat scabies empirically? 

    Page, Tanya L.; Eiff, M. Patrice; Judkins, Dolores Zegar (Family Physicians Inquiries Network, 2007-07)
    Empirically treat patients when they have pruritus and lesions typical of scabies in at least 2 places—even if there is no known household contact diagnosed with scabies, and even if the diagnosis cannot be confirmed by ...

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