Alcoholic liver disease: Is acetaminophen safe?

Abstract

Yes—acetaminophen is a safe and effective analgesic that can be appropriately used for adult patients with stable chronic alcoholic liver disease for at least a short period of time (studies have been limited to a maximum of 48-72 hours), up to the maximum recommended dosage of 4 g daily (strength of recommendation: A, based on 2 RCTs and other studies). There are little data to guide longer-term use of acetaminophen in this situation.