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    Does warfarin prevent venous thromboembolic events in aPL-positive patients?

    Mazzone, Michael F.
    Jamieson, Barbara
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    [PDF] DoesWarfarinPreventVenous.pdf (122.6Kb)
    Date
    2007
    Format
    Article
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    Abstract
    Yes, warfarin is effective in the secondary prevention of venous thromboembolic events (VTEs) for patients positive for lupus anticoagulant or anticardiolipin antibody (also known as antiphospholipid antibodies [aPL]) (strength of recommendation [SOR]: B, single cohort study, extrapolation from other RCTs). Patients should be treated for at least a year (SOR: C, consensus statement), and possibly indefinitely, with warfarin (SOR: B, small clinical trials and cohort studies). Moderate-intensity therapy (international normalized ratio [INR] range, 2.0-3.0) appears to be the best balance between risks and benefits (SOR: B, based on meta-analysis of 2 small randomized control trials.
    URI
    http://hdl.handle.net/10355/3608
    Part of
    Journal of family practice, 56, no. 04 (April 2007): 309+
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
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    • Clinical Inquiries, 2007

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