Does warfarin prevent venous thromboembolic events in aPL-positive patients?

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Does warfarin prevent venous thromboembolic events in aPL-positive patients?

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dc.contributor.author Mazzone, Michael F.
dc.contributor.author Jamieson, Barbara
dc.date.accessioned 2009-11-13T21:32:04Z
dc.date.available 2009-11-13T21:32:04Z
dc.date.issued 2007-04 en
dc.identifier.citation Journal of Family Practice, 56(4) 2007: 309+. en
dc.identifier.uri http://hdl.handle.net/10355/3608
dc.description.abstract Yes, warfarin is effective in the secondary prevention of venous thromboembolic events (VTEs) for patients positive for lupus anticoagulant or anticardiolipin antibody (also known as antiphospholipid antibodies [aPL]) (strength of recommendation [SOR]: B, single cohort study, extrapolation from other RCTs). Patients should be treated for at least a year (SOR: C, consensus statement), and possibly indefinitely, with warfarin (SOR: B, small clinical trials and cohort studies). Moderate-intensity therapy (international normalized ratio [INR] range, 2.0-3.0) appears to be the best balance between risks and benefits (SOR: B, based on meta-analysis of 2 small randomized control trials. en
dc.language.iso en_US en
dc.publisher Family Physicians Inquiries Network en
dc.relation.ispartof Clinical Inquiries, 2007 (MU) en
dc.subject lupus en
dc.subject anticardiolipin antibody en
dc.subject aspirin en
dc.subject.lcsh Warfarin en
dc.subject.lcsh Phospholipid antibodies en
dc.subject.lcsh Cerebral embolism and thrombosis -- Prevention en
dc.title Does warfarin prevent venous thromboembolic events in aPL-positive patients? en
dc.type Article en
dc.relation.ispartofcommunity University of Missouri-Columbia. School of Medicine. Department of Family and Community Medicine. Family Physicians Inquiries Network


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