Is prophylactic anticoagulation safe and effective in older adults with atrial fibrillation?
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Older adults with atrial fibrillation have fewer strokes with oral anticoagulation (OAC) compared with no treatment or antiplatelet therapy, but do have a small increased risk of intracranial hemorrhage (SOR: A, meta-analysis of RCTs). Dabigatran 150 mg PO BID may be more effective than warfarin for preventing strokes with a similar risk of bleeding events (SOR: B, single RCT).
Evidence Based Practice 16(7): 08.