Is guaifenesin safe during pregnancy?
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It's not clear; little evidence supports or refutes the safety of guaifenesin, a common expectorant, in pregnancy. A small number of observational and case-control studies suggest a weak association between guaifenesin use and inguinal hernias and neural tube defects in newborns. However, substantial methodological flaws, the absence of statistical significance, and low rates of prevalence cast a shadow of a doubt over the data (strength of recommendation [SOR]: B, based on observational and case- control studies).
Journal of Family Practice, 56(8) 2007: 669-670.