What treatment approach to intrapartum maternal fever has the best fetal outcomes?
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A combination of beta-lactam and amino-glycoside antibiotics are the recommended empiric agents for the treatment of acute chorioamnionitis, given that no head-to-head trials exist (strength of recommendation [SOR]: C, based on expert opinion). Intrapartum antibiotic treatment is not superior to postpartum antibiotics for reducing neonatal sepsis and pneumonia (SOR: C, based on patient-oriented, underpowered randomized trials).
Clinical Inquiries, 2007 (MU)
Journal of Family Practice, 56(5) 2007: 401-402.