Does use of hydrochlorothiazide (HCTZ) increase the risk of gout?
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Thiazide diuretics (at a dose of more than the equivalent of 25 mg/d HCTZ) are associated with the initiation of anti-gout therapy in older subjects (SOR: B, cohort study). Use of thiazide diuretics significantly increases risk of recurrent gout attacks in people with preexisting gout (SOR: C, case-control study). HCTZ combined with triamterene increases the risk of gouty arthritis in older people, particularly those with elevated baseline uric acid and creatinine levels (SOR: B, RCT).
Evidence Based Practice 16(4): 08.