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    • University of Missouri-Columbia
    • Graduate School - Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Dissertations (MU)
    • 2012 Dissertations (MU)
    • 2012 MU dissertations - Access restricted to MU
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    Mechanisms of inhibition and resistance to antiviral drugs targeting human immunodeficiency virus type 1 (HIV-1) and hepatitis B virus (HBV)

    Michailidis, Eleftherios
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    [PDF] research.pdf.pdf (6.234Mb)
    [PDF] short.pdf (158.9Kb)
    Date
    2012
    Format
    Thesis
    Metadata
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    Abstract
    [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Although human immunodeficiency virus type 1 (HIV-1) and hepatitis B virus (HBV) are very different viruses, the replication of their genome involves a reverse transcription process catalyzed by the viral reverse transcriptase (RT). Nucleoside reverse transcriptase inhibitors (NRTIs) are widely used for the treatment of HIV-1 and HBV infections. Unfortunately, the viruses manage to escape treatment by developing resistance. The main focus of this research is EFdA, a deoxyadenosine analog which blocks HIV-1 replication with remarkable potency. The inhibition stems mainly from the inability of the EFdA-terminated primer to translocate which is a novel mechanism therefore we termed EFdA as a translocation defective RT inhibitor (TDRTI). EFdA is shown here to be very effective not only against wild-type viruses but also against viruses that are resistant to widely used antiretrovirals.
    URI
    https://hdl.handle.net/10355/36771
    https://doi.org/10.32469/10355/36771
    Degree
    Ph. D.
    Thesis Department
    Microbiology (Medicine) (MU)
    Rights
    Access is limited to the campus of the University of Missouri--Columbia.
    Collections
    • Molecular Microbiology and Immunology electronic theses and dissertations (MU)
    • 2012 MU dissertations - Access restricted to MU

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