Browsing 2013 MU dissertations - Freely available online by Title "Two stage adaptive optimal design with applications to dose-finding clinical trials"
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Two stage adaptive optimal design with applications to dose-finding clinical trials
(University of Missouri--Columbia, 2013)In adaptive optimal designs, each stage uses an estimate of the locally optimal design derived using cumulative data from all prior stages. This dependency on prior stages a ffects the properties of maximum likelihood ...