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    Green nanotechnology from tea : phytochemicals in tea as building blocks for production of biocompatible gold nanoparticles

    Nune, Satish K.
    Chanda, Nripen
    Shukla, Ravi
    Katti, Kavita K.
    Kulkarni, Rajesh R.
    Thilakavathy, Subramanian
    Mekapothula, Swapna
    Kannan, Raghuraman
    Katti, Kattesh V.
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    [PDF] GreenNanotechnologyTea.pdf (5.564Mb)
    Date
    2009
    Format
    Article
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    Abstract
    Phytochemicals occluded in tea have been extensively used as dietary supplements and as natural pharmaceuticals in the treatment of various diseases including human cancer. Results on the reduction capabilities of phytochemicals present in tea to reduce gold salts to the corresponding gold nanoparticles are presented in this paper. The phytochemicals present in tea serve a dual role as effective reducing agents to reduce gold and also as stabilizers to provide a robust coating on the gold nanoparticles in a single step. The tea-generated gold nanoparticles (T-AuNPs), have demonstrated remarkable in vitro stability in various buffers including saline, histidine, HSA, and cysteine solutions. T-AuNPs with phytochemical coatings have shown significant affinity toward prostate (PC-3) and breast (MCF-7) cancer cells. Results on the cellular internalization of T-AuNPs through endocytosis into the PC-3 and MCF-7 cells are presented. The generation of T-AuNPs follows all principles of green chemistry and T-AuNPs have been found to be non toxic as assessed through MTT assays. No 'man made' chemicals, other than gold salts, are used in this truly biogenic, green nanotechnological process thus paving the way for excellent opportunities for their application in molecular imaging and therapy.
    URI
    http://hdl.handle.net/10355/3765
    Part of
    Electron Microscopy Core Facility publications (MU)
    Citation
    J. Mater. Chem., 2009, 19, 2912-2920
    Rights
    OpenAccess
    This work is licensed under a Creative Commons Attribution-NonCommerical-NoDerivs 3.0 License.
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    • Electron Microscopy Core Facility publications (MU)

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