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    Effect of Antiepileptic Drugs on Oral Contraceptives

    Carl, Jenny S.
    Weaver, Sally P.
    Tweed, Elizabeth M.
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    [PDF] EffectAntiepilepticDrugs.pdf (86.82Kb)
    Date
    2008
    Format
    Article
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    Abstract
    We found no studies that measure, or even estimate, any increase in pregnancy rates in women taking antiepileptic drugs. Antiepileptic drugs known to induce the hepatic cytochrome P450 (CYP450) isoenzyme cause decreased sex hormone levels in women taking oral contraceptives, raising the potential for decreased effectiveness of oral contraceptives and increased risk of unplanned pregnancy. (Strength of Recommendation [SOR]: C, based on small cohort studies). Antiepileptic drugs that do not induce this hepatic isoenzyme are not thought to compromise the effectiveness of oral contraceptives. (SOR: C, based on small cohort studies and randomized controlled trials).
    URI
    http://hdl.handle.net/10355/3783
    Part of
    Journal of family practice, 57, no. 08 (September 2008): 634+.
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
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    • Clinical Inquiries, 2008

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