How do you evaluate macrocytosis without anemia?
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Start with a detailed history, paying particular attention to medications and alcohol use (strength of recommendation [SOR]: B, prospective cohort studies). Blood testing can include a peripheral smear, evaluation for vitamin deficiencies (especially B12 deficiency), and liver function tests (SOR: B, inconsistent prospective cohort studies).
Journal of Family Practice, 57(8) 2008: 548-550.