Which drugs are most effective for moderate to severe depression in adolescents?

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Which drugs are most effective for moderate to severe depression in adolescents?

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Title: Which drugs are most effective for moderate to severe depression in adolescents?
Author: Guirguis-Blake, Janelle; Wright, Andrew; Rich, Joanne
Keywords: combination therapy
tricyclic antidepressants
side effects
Date: 2008-05
Publisher: Family Physicians Inquiries Network
Citation: Journal of Family Practice, 57(5) 2008: 330+.
Abstract: Fluoxetine is the only selective serotonin-reuptake inhibitor (SSRI) approved by the US Food and Drug Administration (FDA) to treat depression in children 8 years of age and older; it also has the most favorable benefit-to-risk profile compared with placebo in trials lasting up to 12 weeks (strength of recommendation [SOR]: A, meta-analysis). Fluoxetine combined with cognitive behavioral therapy (CBT) is superior to fluoxetine alone, CBT alone, or placebo (SOR: B, single well-done randomized controlled trial [RCT]). Further research is needed to address the long-term efficacy of fluoxetine treatment.
URI: http://hdl.handle.net/10355/3840

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