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    • Clinical Inquiries, 2008
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    Which drugs are most effective for moderate to severe depression in adolescents?

    Guirguis-Blake, Janelle
    Wright, Andrew
    Rich, Joanne
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    [PDF] WhichDrugsEffectiveDepressionAdolescents.pdf (192.0Kb)
    Date
    2008
    Format
    Article
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    Abstract
    Fluoxetine is the only selective serotonin-reuptake inhibitor (SSRI) approved by the US Food and Drug Administration (FDA) to treat depression in children 8 years of age and older; it also has the most favorable benefit-to-risk profile compared with placebo in trials lasting up to 12 weeks (strength of recommendation [SOR]: A, meta-analysis). Fluoxetine combined with cognitive behavioral therapy (CBT) is superior to fluoxetine alone, CBT alone, or placebo (SOR: B, single well-done randomized controlled trial [RCT]). Further research is needed to address the long-term efficacy of fluoxetine treatment.
    URI
    http://hdl.handle.net/10355/3840
    Part of
    Journal of family practice, 57, no. 05 (May 2008): 330+.
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
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